Abstract:

To investigate the effects of extragenous Adrenomedullin (ADM) on the score of the renal tubule in rats with early renal mechanical trauma. Methods104 healthy adult plain grade Wister rats were randomly divided into four groups:8 in the control group, 32 in the trauma group, 32 in the group treated with ADM before trauma, and 32 in the group treated with ADM after trauma. The experimental models were prepared by free dropping a ferrous hammer in the last three groups. ADM（0.1?nmol/kg） was intrapertoneally administrated 10 minutes before trauma or after trauma in the ADM groups. Renal tissues  determined the pathotransform changes by HE staining. ResultsThe score of the renal tubule was distinctively increased in the early phase (1?h and 6?h) (P＜0.05) but significantly decreased to the level of the control group in the late phase post trauma(12?h and 24?h)(P＞0.05). ConclusionExtragenous ADM can protect the kidney, which has relations to the time of intervention.

Key words:  Kidney; Trauma; Adrenomedullin； Score of the Renal Tubule