JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Expressions of EGFR, NM23 and BCL2 in hypopharyngeal cancer and their clinical significance　

YANG Qiuan1,　YANG Jinxia1,　FU Weijiang1,　ZHANG Tingguo2,　WANG Yan2,　LIU Wenjun2,　ZHANG Xiaomei1,　ZHAO Weiping1
   

  1. (1. Cancer Center; 2 Department of Pathology, Qilu Hospital of Shandong University, Jinan 250012, China)
  • Received:1900-01-01 Revised:1900-01-01 Published:2009-04-16
  • Contact: ZHAO Weiping

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Abstract: To investigate expressions of EGFR, NM23 and Bcl2 in hypopharyngeal cancer and their correlation with clinicopathological risks. MethodsExpressions EGFR, NM23 and Bcl2 in 29 cases of hypopharyngeal cancer were determined with an immunohistochemical SP method. ResultsExpressions of EGFR, NM23 and Bcl2 in hypopharyngeal cancer were 62% (18/29), 79% (23/29) and 86% (25/29) respectively. The EGFR level in poorly differentiated cancer was significantly higher than that in well or moderately differentiated cancer (P=0.021), and the EGFR level in the group with unilateral and bilateral lymph node metastases was significantly higher than that in the group without lymph node metastases (P=0.018). However, expressions of NM23 and Bcl2 had no correlation with clinicopathological changes. ConclusionExpression of EFGR is correlated with pathological differentiation and lymph node metastasis, and EFGR may be a potential biomarker for assessing hypopharyngeal cancer. NM23 and Bcl2 need to be further warranted.

Key words: Hypopharyngeal cancer, Epidermal growth factor receptor, NM23, B cell lymphoma

CLC Number: 

  • R739.63
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