Abstract: To investigate the ability of percutaneous penetration of penciclovir microemulsions. MethodsFranz diffusion cells were used in vitro permeation studies and a selfmade open container was used in vivo permeation according to the references. The concentration of penciclovir in the receptor solution、 epidermis and dermis was determined by HPLC and compared with that of the commercial futan cream. ResultsIn vitro the Qn of penciclovir of the microemulsions at 12 hours was 35 times higher than that of the futan creams, however in vivo the penciclovir concentration in the dermis was obviously higher following microemulsion application compared with that following the cream application. ConclusionThe trans-dermal delivery ability of penciclovir is significantly increased with microemulsions compared with the commercial futan cream.

Key words: Penciclovir, Microemulsions, Cutaneous drug administration