Abstract: To investigate the protective effects of Cinepazide Maleate on myocardial ischemia-reperfusion injury during open heart surgery. Methods Thirty adult patients subjected to open heart surgery were randomly divided into the experimental group (group E, n=15) and the control group (group C, n=15). Each group underwent mild hypothermic extracorporeal circulation, and 160mg (4mL)Cinepazide Maleate was added into the cold bloody cardioplegia solution in group E and physiological saline (4mL) was added into group C. The creatine kinaseMB isoenzyme (CKMB) and cardiac Troponin I (cTnI) levels at 0.5, 5 and 24h after aortic crossclamp removal were determined and the corresponding changes in hemodynamics were observed. Results① The self-rebeating rate of hearts was significantly higher in group E than in group C (73% vs 33%) (P＜0.05). ② Changes in hemodynamics were not significantly different between the two groups, but the dose of dopamine in 24 hours was significantly lower in group E than in group C［(382±28)mg vs (404±23)mg］ (P＜0.05). ③ Periods of postoperative mechanical ventilation, and hospital ICU stay were significantly shorter in group E (P＜0.05), also the postoperative stay of group E was shorter than that of group C, but there was no obvious difference between the them. ④ After aortic crossclamp removal, CKMB levels at 0.5, 5, 24h and cTnI levels at 0.5h were significantly lower in group E than in group C (P＜0.05), even more, ConclusionCinepazide Maleate could enhance myocardial protective effects on ischemia-reperfusion injury during open heart surgery, and it significantly decreases the CKMB and cTnI levels and improves cardiac functional restoration.

Key words: Cinepazide maleate, Myocardial ischemiareperfusion injury, Extracorporeal circulation, Creatine kinaseMB isoenzyme, cardiac Troponin I