JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Expressions of kallikrein 7 and 14 in human epithelial ovarian cancer and its clinical significance

GU Shuang1，WANG Qing2，ZHANG Yi-ming3，YUAN Cai-xia1，ZHANG Xiang-ning1   

  1. 1. Department of Gynecology and Obstetrics, Qilu Hospital of Shandong University, Jinan 250012, China; 2. Department of Obstetrics and Gynecology, People′s Hospital of Shanting District, Zaozhuang 277145
  • Received:2007-12-02 Revised:1900-01-01 Online:2008-02-16 Published:2008-02-16
  • Contact: ZHANG Xiang-ning

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Abstract: To evaluate the expressions of kallikrein 7(KLK7) and 14(KLK14) in human epithelial ovarian cancers and to discuss its clinical significance in malignant tumors. Methods RT-PCR and Westernblot were used to determine the expressions of KLK7 and KLK14 mRNA and proteins in 50 epithelial ovarian cancers with different clinical stages and different histological grades. ResultsThe expressions of KLK7 mRNA and protein in ovarian cancers were significantly higher than those in benign tumors（P＜0.01）and were markedly associated with the histological differentiation （P＜0.01）, also the expressions of KLK14 mRNA and protein in ovarian cancers were higher than those in benign tumors（P＜0.05）and were associated with the histological differentiation(P＜0.05), and the expression of KLK14 in advanced stages (Ⅲ and Ⅳ stage) was higher than that in early stages (Ⅰ　and Ⅱ　stage, P＜ 0.01). ConclusionKLK7 and KLK14 play potential roles in the pathogenesis and metastasis of ovarian cancer.

Key words: Kallikrein 7, Kallikrein 14, Ovarian neoplasms

CLC Number: 

  • R737.31
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