JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Expressions and significance of p53 proteins in simple intestinal metaplasia, atypical intestinal

ZHAO Zhu-mei, ZHANG Jian-ping, YANG Jing-yan, LIU Wen-jun, WANG Yan, ZHOU Zhi-qiang   

  1. Department of Pathology, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2007-11-05 Revised:1900-01-01 Online:2008-02-16 Published:2008-02-16
  • Contact: ZHANG Jian-ping

PDF (PC)

477

Abstract: To study the expressions of p53 in simple intestinal metaplasia(SIM), atypical intestinal metaplasia(AIM)and gastric adenocarcinoma. MethodsThe immunohistochemical EnVision method was used to determine the expressions of p53 in simple intestinal metaplasia(SIM), atypical intestinal metaplasia(AIM)and gastric adenocarcinoma. ResultsThe positive rates of p53 in SIM, AIM and gastric adenocarcinoma was 13.6％, 40.0％ and 55.0％. The expression of p53 in AIM was significantly higher than that in SIM. There was no significant differences between AIM and gastric adenocarcinoma. Conclusionp53 may play an important role in intestinal meteplasia and gastric carcinoma.

Key words: Simple intestinal metaplasia, Atypical intestinal metaplasia, Protein p53

CLC Number: 

  • R365
[1] LI Yu-sheng, HUANG Li, L Qi-jun, YU Yong-qin. Effect of interferon α-2b combined with 5-fluorouracil on the biological behavior of hepatoma cells [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(9): 48-.
[2] LI Zhen-xiang1, DU Jia-jun1, LIN Xiao-yan2, MU Xue-ru1, WANG Li-guang1, LIU Qi1. Expressions of HIF-1α and P53 in bronchioloalveolar carcinoma and lung adenocarcinoma with mixed subtypes and their significance [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(6): 94-98.
[3] KONG Fanrong1,　WANG Liming1,　DAI Shuzhen1,　SUN Xianlu2,　L Yanhua1

. Expressions of B7H4, CA125 and P53 in epithelial
ovarian cancer and their clinical value [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(02): 74-77.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd