JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Expression of TGFβR/Smads in endometrioid adenocarcinoma cancer cells and stromal cells

WANG Fu-ling, HAN Xue-chuan, ZHAO Xing-bo，LI Ming-jiang, LI Ji-jun   

  1. Department of Obstetrics and Gynecology， Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
  • Received:2008-03-03 Revised:1900-01-01 Online:2008-10-16 Published:2008-10-16
  • Contact: ZHAO Xing-bo

PDF (PC)

493

Abstract: To investigate the relationship between the status of the TGFβR/Smads signal pathway in cancer cells and in its stromal cells, and if this may affect the development of endometrioid adenocarcinoma. MethodsTGFβRⅠ, TGFβRⅡ, Smad2, Smad3, Smad4 and Smad7 were determined in hysteromyoma (12 cases) and endometrioid adenocarcinoma (18 cases) by the SP immunohistochemical method. ResultsTGFβRⅠ, TGFβRⅡ, Smad2, Smad3, Smad4 and Smad7 were found in hysteromyoma. TGFβR expression which was in positive correlation with Smads expression in normal endometrium cells(r=0.86, r=0.78). TGFβR/Smads expression disagreed in endometrial cancer cells and stromal cells and it was not found in stromal cells of endometrial adenocarcinoma per se. ConclusionsTGFβR/Smads signals exist in cells of normal endometrial proliferative /secretory phase but its pathway is defected in tumor stroma. To get the information about TGFβR/Smads signal way in stroma probably provides a neotarget for gene therapy of endometrioid carcinoma.

Key words: Endometrial neoplasms, Stromal cell, Transforming growth factorβ receptor, Smads

CLC Number: 

  • R737.33
[1] LI Yuanyuan, ZHANG Nan, XU Mi, QIN Mingming, DOU Dongdong, ZHU Weiwei. Expression of stromal cell derived factor-1α and its effects in hypoxic-ischemic brain tissue of neonatal mice [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(10): 26-31.
[2] LIU Yang1, LI Wei-hua1, L Qing-tao2, YANG Ning1, JIANG Jie1. Expression of DACH1, fatty acid synthase and sterol regulatory element binding protein-1 in endometrial carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(4): 71-76.
[3] CHEN Hai-yan, YAO Shu-zhe, ZHANG Xiao-ying, ZHANG Jian-ping, ZHANG Cui-juan, ZHANG Ting-guo. Effect of the methylation of SOCS-3 and 3-OST-2 genes in endometrial cancer and its clinical pathological significances [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2013, 51(06): 75-80.
[4] REN Min1, L Yi-jing1, ZHANG Ji-dong1, Wang Bo1, LIU Ping2. Inhibitory effect of the Qindan capsule on proliferation and migration of adventitial fibroblasts [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(6): 71-.
[5] MA Ben-hong1, ZHANG Gui-yu1, LIANG Jing1, ZU Zeng-yan2, LI Yue1. Expression and significance of the HMGB1 protein  in endometrial adenocarcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(6): 144-148.
[6] NAN Fang-fang1， WEI Shuang-yan1， JIANG Jie2， CHENG Lei3. Expression of cyclin D1 protein in endometrial carcinoma and its clinical significance [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(11): 151-155.
[7] CUI Jun1, XU Xin1,2, MA Yue1, DONG Pengfei3, LIU Gangli1, WEN Yong1. A preliminary experimental study on bone marrow stromal cell biocompatibility of carboxymethyl chitosan calcium [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(6): 57-60.
[8] ZU Zengyan1, ZHANG Guiyu1, MA Benhong1, WANG Hongxia2 . Inhibitory effect of rosiglitazone combined with cisplatin on the growth of endometrial carcinoma in Nude Mice [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(5): 62-66.
[9] LIU Jie,YANG Xing-sheng,QU Xun,LI Hua,ZHONG Yan-hui. Relation among single nucleotide polymorphism in estrogen metablolizing genes CYP17, COMT and endometrial adenocarcinoma risk [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(1): 18-21.
[10] XIE Min,WEI De-e,WANG Bo,LU Ai-ying. Heterozygosity loss at FHIT, SLIT2 and EDNRB gene in endometrical carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(1): 90-93.
[11] NAN Fang-fang,JIANG Jie,XIA Min,DONG Zhe,FENG Jin-bo. Expression of the RASSF1A gene in endometrial carcinoma and its clinical significance [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(1): 94-96.
[12] WANG Zhi-yong,CHEN Hai-zeng,YU Shang-ji. [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(11): 1090-1094.
[13] WU Xi-mei,ZHANG Shi-qian,ZHOU Xiao-liang,SHI Yan. Expression of MAGE, GAGE and BAGE genes in endometrial carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(10): 1004-1007.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd