Abstract: Objective： To explore the correlation of serum tissue polypeptide antigen（TPA）and the soluble vascular cell adhesion molecule-1(sVCAM-1) and pathogenesis of pre-eclampsia. Methods： ELISA was used to determine the serum of TPA and sVCAM-1 in pre-eclamptic(the experimental group) and normotensive pregnant( the control group) women, and the correlation of pre-eclampsia (PE) and neonatal outcomes was analyzed by rank correlation. Results： (1) Concentration of serum TPA in the experimental group was obviously higher than that in the control group (P＜0.05) and it was the highest in patients with serious pre-eclampsia（P＜0.01）. (2) Concentration of serum sVCAM-1 in the severe experimental group was obviously higher than that in the mild experimental and the control groups (P＜0.01). (3) There was a significantly positive correlation between the TPA and the sVCAM-1 in the experimental and control groups. (4) There were a significantly positive correlation between the TPA and sVCAM-1 and the DBP and urine protein in the experimental group, and a significantly negative correlation between the TPA and the sVCAM-1 and the weight of newborns. Conclusion： With the state of the disease worsening, serum TPA and sVCAM-1 is increased, indicating that the apoptosis of the trophoblast cells and the dysfunction of the vascular endothelial cells are aggravated.

Key words: Preeclampsia, Tissue polypeptide antigen, Soluble vascular cell adhesion molecule-1, Neonatal weight