JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Expression of TGFβ1 and BMP-2 in the experimental ligamentum flavum of the unstable cervical spine

ZHANG Xi-shan1，2，CAI Guo-dong2，LI Jian-min1，YANG Ming-feng3   

  1. 1. Department of Osteology, Qilu Hospital of Shandong University; 2. Department of Osteology, Affiliated Hospital of Taishan Medical College, Tai′an 271000;3. Basic Medical Research Center, Taishan Medical College, Tai′an 271000
  • Received:2007-08-23 Revised:1900-01-01 Online:2007-12-24 Published:2007-12-24
  • Contact: ZHANG Xi-shan

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Abstract: Objective To study the effects of the unstable cervical spine on transforming growth factor-β1(TGFβ1) and bone morphogenetic protein-2 (BMP2) of the ligamentum flavum in rats. MethodsTotal RNA was prepared from ligamentum flavum of the experimental segment of different groups and the expressions of TGFβ1 and BMP2 was determined by reverse transcriptase polymerase chain reaction using specific primers. Result The gene expression of the unstable cervical spinegroup was higher than that of the control groups in each time spots. Conclusion The expression of TGFβ1 and BMP2 in the ligamentum flavum in rats with unstable cervical spine is different by time spots, which may accelerate the degeneration of the ligamentum flavum.

Key words: Transforming growth factor beta 1, Bone morphogenetic protain 2, Ligamentum flavum, Reverse transcriptase polymerase chain reaction

CLC Number: 

  • R681.5
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