JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Effect of Puerarin on Cathepsin S and Cystatin C during the procedure of vascular restenosis in balloon injured rabbits

WANG Qun, LU Qing-hua, JIANG Wei-dong, LIU Yu-sheng, DU Yi-meng, DONG Zhao-qiang, WANG Xin,HAO Lin, QIN Ai-qiong, XU Dong-ling, SHENG Lin   

  1. Department of Cardiovascular Disease, Second Hospital of Shandong University, Jinan 250033, China
  • Received:2007-08-30 Revised:1900-01-01 Online:2007-11-24 Published:2007-11-24
  • Contact: LU Qing-hua

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Abstract: ObjectiveTo explore the effects of Puerarin on Cathepsin S and Cystatin C during the procedure of vascular restenosis after balloon injury. MethodsThe experimental models of vascular restenosis in rabbits were established by anendothelial injury induced by a balloon and hyper-lipid feed. The arterious restenosis area, expressions of Cathepsin S and Cystatin C, and the differences of collagen were determined. ResultsAt the end of 8 weeks after an endothelial injury by a balloon, the restenosis area in the Puerarin group(100mg/kg per day) was obviously smaller than that in the balloon injured group（P<0.05）. The expression of Cathepsin S in the Puerarin group was lighter than that in the balloon injured group (P<0.05), however the expression of Cystatin C was not significantly different between the Puerarin group and the balloon injured group (P>0.05). Collagen in the intima was significantly decreased in the Puerarin group compared with that in the balloon injured group (P<0.01). ConclusionPuerarin has a regressive effect on vascular restenosis in rabbits by modulating the expression of Cathepsin S and reducing collagen accumulation in the vascular restenosis area, but it does not affect the expression of Cystatin C.

Key words: Puerarin, Restenosis, Matrix remodeling, Cathepsin S, Cystatin C

CLC Number: 

  • R541.4
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