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Effect of Losartan on the permeability of blood-brain barrier and the activity of MMP-9 on focal brain ischemia/reperfusion injury in rats

QU Si-feng, WANG Jia-ni, WEI Xin-bing, ZHANG Jian-wei, WANG Li-xiang, CHEN Lin, SUN Xia   

  1. Institute of Pharmacology, School of Medicine, Shangdong University, Jinan 250012, China
  • Received:2007-05-24 Revised:1900-01-01 Online:2007-10-24 Published:2007-10-24
  • Contact: SUN Xia

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Abstract: Objective： To investigate the effects of AT1 receptor antagonist Losartan on the permeability of blood-brain barrier（BBB）and the activity of matrix metalloproteinase-9 (MMP-9) on cerebral ischemia-reperfusion (IR) in rats. Method： With a model of reversible middle cerebral artery occlusion (MCAO) in rats, the effects of Losartan on the water content of brain, the contents of Evens blue (EB) and the expression of MMP-9 were investigated after 24 hours of reperfusion following two hours of cerebral ischemia. Results： After 24 hours of reperfusion following two hours of cerebral ischemia, the cerebral water content and the contents of EB were increased while MMP-9 was highly expressed. The content of EB in the Losartan group was significantly lower than that in the ischemia/ reperfusion (IR) group (P＜0.05)． Conclusion： Losartan may decrease the activity of MMP-9 and the permeability of bloodbrain barrier in cerebral IR rats．

Key words: Losartan, Angiotensin Ⅱ, Brain ischemia-reperfusion, Blood-brain barrier, Matrix metalloproteinase-9

CLC Number: 

  • Q95-33
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