JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Role of saponins on MCP1 and ET in serum and cerebrospinalfluid of patients with acute brain infarction

WANG Pin, YU Jun, ZHOU Qing-bo, XIE Zhao-hong, BI Jian-zhong, WANG Xiao-yun, LIU Zhen, SUN Lin, WANG Ping   

  1. .Department of Neurology,Second Hospital of Shandong University, Jinan 250033, Shandong, China;2.Department of Prevention of Infection, Affiliated Hospital of Shandong University ofTraditional Chinese Medicine, Jinan 250012, Shandong, China
  • Received:2005-10-29 Revised:1900-01-01 Online:2006-05-24 Published:2006-05-24
  • Contact: WANGPIN

Abstract: To investigate the concention changes of the monocyte chemoattractant protein1(MCP1) and the endothelia(ET) in serum and cerebrospinal fluid(csf) of patients with acute brain infarction treated by saponins. Methods: The level of MCP1and ET in different times in serum and cerebrospinal were determined by enzymelinked immunoadsordent (ELLISA) and radioreceptor assay (RRA). CSF samples were obtained on the first day of the onset and at 48 hours later during the lumbar puncture procedure. Results: Both the serum levels of MCP1 and ET in different times were notably higher in ischemic stroke than healthy man(P<0.05). The level of MCP1 reached the peak on the day 3 and then decreased on the day 510, and that of ET, too.The levels of MCP

Key words: Brain infarction, Saponins, Monocyte chemoattractant protein1,

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