Journal of Shandong University (Health Sciences) ›› 2025, Vol. 63 ›› Issue (12): 17-25.doi: 10.6040/j.issn.1671-7554.0.2025.0723

• Clinical Medicine • Previous Articles    

Clinical analysis of rifampicin-soaked grafts in the treatment of Brucella infection in aorto-iliac artery aneurysms

YANG Jianping, GUAN Sheng, GE Xiaohu   

  1. Department of Vascular Surgery, Peoples Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang, China
  • Published:2025-12-19

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Abstract: Objective To explore the efficacy and safety of rifampicin-soaked grafts in the treatment of Brucella-induced aorto-iliac artery infectious aneurysms. Methods This study retrospectively analyzed the clinical data of 10 consecutive patients with Brucella-induced infectious aneurysms(B-IAA)who received rifampicin-soaked grafts at the Peoples Hospital of Xinjiang Uygur Autonomous Region from October 2016 to November 2021. All 10 patients(9 males and 1 female)underwent emergency/urgent surgery. Seven patients underwent endovascular repair with rifampicin-soaked covered stents, and 3 patients underwent open in situ reconstruction with rifampicin-soaked Dacron grafts. Based on the case data and follow-up information, the 30-day survival rate after surgery, treatment-related complications, re-infection rate, graft patency, and aortic-related mortality were statistically analyzed. Results All 10 patients achieved successful surgery. There were no deaths within 30 days after surgery. Three patients experienced perioperative and postoperative complications. One patient developed coagulation dysfunction and retroperitoneal hemorrhage after surgery and recovered after conservative treatment such as blood transfusion. One iliac artery stent patient developed re-infection 10 months after surgery and underwent open surgery, and died of cerebrovascular disease 15 months later. One patient died of multiple organ failure caused by sepsis 40 days after surgery. The average follow-up was 1-103(41.8±27.6)months. One patient died of unknown causes 2 years after surgery, and one patient developed a small thoracic aortic aneurysm 4 years after endovascular repair of the abdominal aortic aneurysm(no intervention). The remaining patients had no aortic or graft-related interventions. Conclusion Rifampicin-soaked grafts is an effective treatment for B-IAA, and both endovascular and open surgeries have achieved good results.

Key words: Infected arterial aneurysms, Brucellosis, Rifampicin, Endovascular repair, In situ reconstruction

CLC Number: 

  • R654.3
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