Journal of Shandong University (Health Sciences) ›› 2025, Vol. 63 ›› Issue (12): 79-95.doi: 10.6040/j.issn.1671-7554.0.2025.0159

• Clinical Medicine • Previous Articles    

Impact of axial length on circumferential choroidal thickness and vessel density using SS-OCTA

LIU Xuefen1,2,3,4, YANG Ru1,2,3, WANG Shuxia1,2,3, HAO Haitao1,2,3, LIANG Lu1,2,3, LIU Chang5, GONG Rui1,2, JIANG Shuang1,2,3   

  1. 1. The Third of Clinical Medical, Jinzhou Medical University, Jinzhou 121001, Liaoning, China;
    2. Department of Ophthalmology, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou 121002, Liaoning, China;
    3. Collaborative Innovation Center for Children and Adolescents Health Promotion, Jinzhou Medical University, Jinzhou 121001, Liaoning, China;
    4. Department of Clinical Medical, Guangzhou Health Science College, Guangzhou 510500, Guangdong, China;
    5. Department of Ophthalmology, Jinzhou Central Hospital, Jinzhou 121000, Liaoning, China
  • Published:2025-12-19

PDF (PC)

3

CLC Number: 

  • R773.4
[1] Holden BA, Fricke TR, Wilson DA, et al. Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050[J]. Ophthalmology, 2016, 123(5): 1036-1042.
[2] Bai Y, Sui JY, Li HR, et al. Relationship between the structure and microcirculation of the optic disc region and myopic traction maculopathy in highly myopic eyes[J]. Graefes Arch Clin Exp Ophthalmol, 2024, 262(3): 801-811.
[3] Nickla DL, Wallman J. The multifunctional choroid[J]. Prog Retin Eye Res, 2010, 29(2): 144-168.
[4] Yang JY, Wang EQ, Yuan MZ, et al. Three-dimensional choroidal vascularity index in acute central serous chorioretinopathy using swept-source optical coherence tomography[J]. Graefes Arch Clin Exp Ophthalmol, 2020, 258(2): 241-247.
[5] Zhou H, Dai YN, Shi YY, et al. Age-related changes in choroidal thickness and the volume of vessels and stroma using swept-source OCT and fully automated algorithms[J]. Ophthalmol Retina, 2020, 4(2): 204-215.
[6] 张金玲, 廖宇洁, 于晓彦, 等. 不同屈光状态儿童青少年黄斑中心凹下脉络膜厚度变化分析[J]. 眼科新进展, 2024, 44(11): 883-886. ZHANG Jinling, LIAO Yujie, YU Xiaoyan, et al. Changes in the subfoveal choroidal thickness of children and adolescents with different refractive states[J]. Recent Advances in Ophthalmology, 2024, 44(11): 883-886.
[7] 朱锦亭, 冯洁. 光学相关断层扫描血管成像术评估成年近视患者黄斑区视网膜血流密度和视网膜厚度[J]. 中国临床研究, 2024, 37(12): 1895-1899. ZHU Jinting, FENG Jie. Evaluation of macular retinal blood flow density and retinal thickness in adult myopia patients by optical coherence tomography angiography[J]. Chinese Journal of Clinical Research, 2024, 37(12): 1895-1899.
[8] Zhu HL, Liu CY, Gao MJ, et al. Choroidal thickness in relation to diopter and axial length among myopic children[J]. Front Med, 2023, 10: 1241352. doi: 10.3389/fmed.2023.1241352
[9] Yang ZY, Jing RH, Wu YD, et al. Swept-source OCT angiography-derived regional normative data of peripapillary vessel density in healthy populations[J]. Transl Vis Sci Technol, 2025, 14(8): 5. doi: 10.1167/tvst.14.8.5
[10] Borrelli E, Sarraf D, Freund KB, et al. OCT angiography and evaluation of the choroid and choroidal vascular disorders[J]. Prog Retin Eye Res, 2018, 67: 30-55. doi: 10.1016/j.preteyeres.2018.07.002
[11] 韦朋, 房祥杰, 张娟美, 等. 不同屈光状态下儿童青少年黄斑区脉络膜厚度的研究[J]. 山东医学高等专科学校学报, 2025, 47(2): 33-35.
[12] Paritala A, Balaji JJ, Gopalakrishnan A, et al. Profile of peripheral refraction, choroidal thickness, and its correlation with refraction among children with myopia[J]. Indian J Ophthalmol, 2025, 73(8): 1159-1165.
[13] Agrawal R, Gupta P, Tan KA, et al. Choroidal vascularity index as a measure of vascular status of the choroid: Measurements in healthy eyes from a population-based study[J]. Sci Rep, 2016, 6: 21090. doi: 10.1038/srep21090
[14] Ratra D, Tan R, Jaishankar D, et al. Choroidal structu-ral changes and vascularity index in stargardt disease on swept source optical coherence tomography[J]. Retina, 2018, 38(12): 2395-2400.
[15] Shen C, Li Y, Wang Q, et al. Choroidal vascular changes in retinitis pigmentosa patients detected by optical coherence tomography angiography[J]. BMC Ophthalmol, 2020, 20(1): 384. doi: 10.1186/s12886-020-01640-5
[16] Wu H, Zhang GY, Shen MX, et al. Assessment of choroidal vascularity and choriocapillaris blood perfusion in anisomyopic adults by SS-OCT/OCTA[J]. Invest Ophthalmol Vis Sci, 2021, 62(1): 8. doi: 10.1167/iovs.62.1.8
[17] Read SA, Alonso-Caneiro D, Vincent SJ, et al. Longitudinal changes in choroidal thickness and eye growth in childhood[J]. Invest Ophthalmol Vis Sci, 2015, 56(5): 3103-3112.
[18] Rasheed MA, Singh SR, Invernizzi A, et al. Wide-field choroidal thickness profile in healthy eyes[J]. Sci Rep, 2018, 8: 17166. doi: 10.1038/s41598-018-35640-9
[19] Mohler KJ, Draxinger W, Klein T, et al. Combined 60° wide-field choroidal thickness maps and high-definition en face vasculature visualization using swept-source megahertz OCT at 1050 nm[J]. Invest Ophthalmol Vis Sci, 2015, 56(11): 6284-6293. doi: 10.1167/iovs.15-16670
[20] 朱凯敏. 儿童屈光不正与脉络膜厚度和血流的研究[D]. 济南: 山东大学, 2021.
[21] 唐冲, 计岩, 黄凡凡, 等. 基于SS-OCTA的成年近视患者黄斑区脉络膜厚度和血流特点的观察[J]. 重庆医科大学学报, 2025, 50(1): 80-87. TANG Chong, JI Yan, HUANG Fanfan, et al. Features of choroidal thickness and choroidal vascularity in the macular region of adult patients with myopia based on swept-source optical coherence tomography[J]. Journal of Chongqing Medical University, 2025, 50(1): 80-87.
[22] Ellabban AA, Tsujikawa A, Matsumoto A, et al. Three-dimensional tomographic features of dome-shaped macula by swept-source optical coherence tomography[J]. Am J Ophthalmol, 2013, 155(2): 320-328.
[23] May CA. Non-vascular smooth muscle cells in the human choroid: distribution, development and further characterization[J]. J Anat, 2005, 207(4): 381-390.
[24] Stoll C, Alembik Y, Dott B, et al. Epidemiology of congenital eye malformations in 131, 760 consecutive births[J]. Ophthalmic Paediatr Genet, 1992, 13(3): 179-186.
[25] Gupta P, Thakku SG, Saw SM, et al. Characterization of choroidal morphologic and vascular features in young men with high myopia using spectral-domain optical coherence tomography[J]. Am J Ophthalmol, 2017, 177: 27-33. doi: 10.1016/j.ajo.2017.02.001
[26] Read SA, Collins MJ, Vincent SJ, et al. Choroidal thickness in myopic and nonmyopic children assessed with enhanced depth imaging optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2013, 54(12): 7578-7586.
[27] Gao J, Rao CH, Li F, et al. Ultra-widefield swept-source optical coherence tomography angiography in the assessment of choroidal changes in young adults with myopia[J]. Transl Vis Sci Technol, 2022, 11(12): 14. doi: 10.1167/tvst.11.12.14
[28] 卢运庆. 不同级别近视性豹纹状眼底对视网膜脉络膜的影响及相关因素研究[D]. 昆明: 昆明医科大学, 2022.
[29] Uematsu S, Sakaguchi H, Sayanagi K, et al. Association between choriocapillaris flow deficit and choroidal neovascularization activity in eyes with myopic choroidal neovascularization[J]. Sci Rep, 2021, 11(1): 21947. doi: 10.1038/s41598-021-01557-z
[30] Faes L, Bodmer NS, Locher S, et al. Test performance of optical coherence tomography angiography in detecting retinal diseases: a systematic review and meta-analysis[J]. Eye(Lond), 2019, 33(8): 1327-1338.
[31] Fan H, Chen HY, Ma HJ, et al. Reduced macular vascular density in myopic eyes[J]. Chin Med J, 2017, 130(4): 445-451.
[32] Ikuno Y. Overview of the complications of high myopia[J]. Retina, 2017, 37(12): 2347-2351.
[33] Luo H, Sun JF, Chen L, et al. Compartmental analysis of three-dimensional choroidal vascularity and thickness of myopic eyes in young adults using SS-OCTA[J]. Front Physiol, 2022, 13: 916323. doi: 10.3389/fphys.2022.916323
[34] 陈亚茹, 徐梦月, 刘艳, 等. 扫频OCTA观察不同眼轴近视患者视网膜-脉络膜血流及厚度的变化[J]. 右江民族医学院学报, 2024, 46(4): 525-537. CHEN Yaru, XU Mengyue, LIU Yan, et al. SS-OCTA for observing retinal and choroidal blood flow and thickness changes in myopic patients with different axial lengths[J]. Journal of Youjiang Medical University for Nationalities, 2024, 46(4): 525-537.
[35] Zhang WR, Li C, Gong YB, et al. Advanced ultrawide-field optical coherence tomography angiography identifies previously undetectable changes in biomechanics-related parameters in nonpathological myopic fundus[J]. Front Bioeng Biotechnol, 2022, 10: 920197. doi: 10.3389/fbioe.2022.920197
[36] Wu H, Chen W, Zhao F, et al. Scleral hypoxia is a target for myopia control[J]. Proc Natl Acad Sci U S A, 2018, 115(30): E7091-E7100.
[37] Yin XF, Ge JL. The role of scleral changes in the progression of myopia: a review and future directions[J]. Clin Ophthalmol, 2025, 19: 1699-1707. doi: 10.2147/OPTH.S523283
[38] Huang LX, Zhang JJ, Luo YF. The role of atropine in myopia control: insights into choroidal and scleral mechanisms[J]. Front Pharmacol, 2025, 16: 1509196. doi: 10.3389/fphar.2025.1509196
[39] Khan MH, Lam AKC, Armitage JA, et al. Impact of axial eye size on retinal microvasculature density in the macular region[J]. J Clin Med, 2020, 9(8): 2539. doi: 10.3390/jcm9082539
[40] Tang XC, Liang J, Luo LS, et al. Investigation of choroidal vascular alterations in eyes with myopia using ultrawidefield optical coherence tomography angiography[J]. BMJ Open Ophthalmol, 2024, 9(1): e001839. doi: 10.1136/bmjophth-2024-001839
[41] Flores-Moreno I, Lugo F, Duker JS, et al. The relationship between axial length and choroidal thickness in eyes with high myopia[J]. Am J Ophthalmol, 2013, 155(2): 314-319.
[42] Gupta P, Saw SM, Cheung CY, et al. Choroidal thickness and high myopia: a case-control study of young Chinese men in Singapore[J]. Acta Ophthalmol, 2015, 93(7): 585-592.
[43] Chung SE, Kang SW, Lee JH, et al. Choroidal thickness in polypoidal choroidal vasculopathy and exudative age-related macular degeneration[J]. Ophthalmology, 2011, 118(5): 840-845.
[44] Ohno-Matsui K, Jonas JB. Posterior staphyloma in pathologic myopia[J]. Prog Retin Eye Res, 2019, 70: 99-109. doi: 10.1016/j.preteyeres.2018.12.001
[45] KhalafAllah MT, El Hamdaoui M, Fuchs PA, et al. Early peripapillary choroidal thinning during myopia development: a potential biomarker for progressive myopia identified in tree shrews[J]. Invest Ophthalmol Vis Sci, 2025, 66(11): 11. doi: 10.1167/iovs.66.11.11
[46] Hirata A, Negi A. Morphological changes of choriocapillaris in experimentally induced chick myopia[J]. Graefes Arch Clin Exp Ophthalmol, 1998, 236(2): 132-137.
[47] Lu HC, Chen HY, Huang CJ, et al. Predicting axial length from choroidal thickness on optical coherence tomography images with machine learning based algorithms[J]. Front Med, 2022, 9: 850284. doi: 10.3389/fmed.2022.850284
[48] Flügel C, Tamm ER, Mayer B, et al. Species differences in choroidal vasodilative innervation: evidence for specific intrinsic nitrergic and VIP-positive neurons in the human eye[J]. Invest Ophthalmol Vis Sci, 1994, 35(2): 592-599.
[1] 王宇雷,曲毅,周芳,冯进波. A diode laserinduced choroidal neovascularization model in Brown Norway rats: an experimental study [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(2): 163-167.
[2] . [J]. Journal of Shandong University (Health Sciences), 2023, 61(5): 119-121.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd