Journal of Shandong University (Health Sciences) ›› 2025, Vol. 63 ›› Issue (2): 36-42.doi: 10.6040/j.issn.1671-7554.0.2024.1186

• Clinical Medicine • Previous Articles     Next Articles

Effect of ω-3 polyunsaturated fatty acids on recovery of autonomic nervous system and intestinal function after laparoscopic colorectal cancer surgery

WANG Gang, XU Pengyan, ZHAO Xuan, WANG Haifeng, GE Miaomiao, PAN Huafeng, JIANG Zhiwei   

  1. Department of General Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine /Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, Jiangsu, China
  • Online:2025-03-10 Published:2025-03-07

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Abstract: Objective To assess the effects of ω-3 polyunsaturated fatty acids on the recovery of autonomic nervous system and intestinal function after laparoscopic colorectal cancer surgery with the assistance of heart rate variability monitoring devices and continuous bowel sound auscultation recorders. Methods A total of 126 patients who underwent laparoscopic radical surgery for colorectal cancer at Jiangsu Province Hospital of Chinese Medicine from February 2022 to June 2024 were selected and randomly divided into an observation group and a control group, with 63 cases in each group. The observation group started oral administration of an enteral nutrition preparation containing ω-3 polyunsaturated fatty acids(Supportan)on the first postoperative day. The control group initiated oral administration of a conventional enteral nutrition preparation(Nutison Fibre)on the first postoperative day. The study observed indicators of intestinal function recovery(time to bowel sound recovery, time to first flatus, length of postoperative hospital stay), heart rate variability indices reflecting autonomic nervous system function(SDNN, pNN50, LF, HF, LF/HF), stress-inflammatory markers(CRP, IL-1β, IL-2, IL-6, TNF-α, IFN-γ), and the occurrence of postoperative complications. Results The observation group had earlier recovery times for bowel sounds, first flatus, and first oral intake compared to the control group, with statistically significant differences(P<0.001). On the first postoperative day, the heart rate variability index pNN50 was higher in the observation group than that in the control group(P=0.031), and on the third day, the heart rate variability indices SDNN, pNN50, and HF were all significantly higher in the observation group than those in the control group(P=0.006, P=0.012, P=0.031). On the third postoperative day, the levels of stress-inflammatory markers CRP, IL-1β and IL-6 were lower in the observation group than those in the control group(P=0.032, P=0.035, P=0.001). There were no statistically significant differences in complication rate after surgery between the groups(P=0.767). Conclusion ω-3 polyunsaturated fatty acids facilitate the recovery of intestinal function after laparoscopic colorectal cancer surgery, maintain postoperative vagus nerve function, and mitigate systemic inflammatory responses.

Key words: Laparoscopic radical resection for colorectal cancer, ω-3 polyunsaturated fatty acids, Gastrointestinal function, Vagus nerve, Heart rate variability monitoring, Continuous bowel sound auscultation records

CLC Number: 

  • R459.3
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