Journal of Shandong University (Health Sciences) ›› 2021, Vol. 59 ›› Issue (8): 1-7.doi: 10.6040/j.issn.1671-7554.0.2021.0861

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Latest research advances on factors that influence endometrial receptivity

CHEN Zijiang1,2,3,4, YAN Junhao1,2,3   

  1. 1. Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan 250001, Shandong, China;
    2. Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Shandong University, Jinan 250001, Shandong, China;
    3. National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan 250021, Shandong, China;
    4. Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
  • Published:2021-09-16

Abstract: Good endometrial condition is essential to successful pregnancy. Endometrial receptivity, the capability of endometrium to receive embryo, will improve during the window of implantation in menstruation cycle, indicating the accurate time for implantation. As reported, 2/3 cases on embryo implantation failure or pregnancy loss were attributed to endometrial dysfunction. Evidence based on studies about bad endometrial receptivity and exact mechanism thereof, will provide effective approaches for diagnosis and treatment of these dysfunctions. In this review, we elaborated multiple underlying factors that influence endometrial receptivity, hoping to provide reference for further studies on pathophysiological mechanisms of endometrium in embryo implantation failure or pregnancy loss.

Key words: Endometrial receptivity, Anatomical factor, Immunological factor, Metabolic factor, Endocrine factor

CLC Number: 

  • R711.32
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