Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (1): 26-30.doi: 10.6040/j.issn.1671-7554.0.2019.969

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Effects of mechanical thrombus aspiration and catheter-directed thrombolysis on venous function in 87 cases of acute central deep venous thrombosis of lower extremity

SUN Xinguo, CHEN Kunhao, HU Zhang, DENG Xiaojun, DUAN Shijiao, XIE Weihua, YAN Qiong, ZHANG Hongwen   

  1. Department of Vascular Surgery, Affiliated Hospital of Nanhua University, Hengyang 421002, Hunan, China
  • Published:2022-09-27

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Abstract: Objective To explore the effects of mechanical thrombus aspiration and catheter-directed thrombolysis(CDT)on venous function of acute central deep venous thrombosis(DVT). Methods A total of 87 patients with acute central DVT treated during Jan. 2015 and Jan. 2017 were selected, including 45 males and 42 females. The patients were divided into 2 groups: mechanical group(n=39, thrombus aspiration with big catheter or sheath, supplemented with small dose of urokinase after operation), and CDT group(n=48). The effective internal diameter of superficial femoral vein(SFV), time of blood regurgitation of the first valve in SFV, reflux distance, and incidence of post-discharge postthrombotic syndrome(PTS)were compared 6 months, 1 year and 2 years after treatment. Results There 山 东 大 学 学 报 (医 学 版)58卷1期 -孙鑫国,等. 机械性血栓抽吸和置管溶栓对87例急性中央型下肢深静脉血栓静脉功能的影响 \=-was significant difference in the diameter of SFV between the two groups(Ftreatment=10 197.500, P<0.001), the differences 6 months, 1 year and 2 years were statistically significant(Ftime=442.770, P<0.001), and there was a synergistic interaction effect between the treatment method and time(Ftreatment×time=317.749, P<0.001). There was significant difference in valvular regurgitation time between the two groups(Ftreatment=14 529.193, P<0.001), the differences 6 months, 1 year and 2 years were significant(Ftime=670.189, P<0.001), and there was a synergistic interaction effect between treatment method and time(Ftreatment×time=501.604, P<0.001). There was significant difference in reflux distance between the two groups(Ftreatment=4 842.897, P<0.001), the differences 6 months, 1 year and 2 years were significant(Ftime=413.343, P<0.001), and there was a synergistic interaction effect between the treatment method and time(Ftreatment×time=313.582, P<0.001). The incidence of PTS was ［35.42%(17/48)］ in CDT group, and ［15.40%(6/39)］ in the mechanical group, with statistical difference(χ2=106.350, P<0.001). Conclusion Mechanical thrombus aspiration can expand the cavity of SFV in the early stage, reduce the time and distance of blood reflux at the valve, reduce the incidence of long-term PTS, and better protect the venous function compared with CDT.

Key words: Thrombus aspiration, Catheterization, Deep venous thrombosis of lower extremities, Venous function of lower extremities

CLC Number: 

  • R543.6
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