Journal of Shandong University (Health Sciences) ›› 2020, Vol. 58 ›› Issue (2): 64-71.doi: 10.6040/j.issn.1671-7554.0.2019.1088

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Distribution and drug resistance change of clinical isolates in ICU of a new hospital

SUN Yanting, WU Dawei, WANG Xiaofei, XU Jian, WANG Rui   

  1. Department of Intensive Care Unit, Qilu Hospital of Shandong University(Qingdao), Qingdao 266035, Shandong, China
  • Online:2020-02-10 Published:2022-09-27

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Abstract: Objective To clarify the distribution and drug resistance change of clinical isolates in ICU of a new hospital, and to provide evidence for clinical infection prevention and management. Methods The distribution and drug sensitivity of positive strains were retrospectively analyzed from January 2014 to December 2018 in ICU. Bacteria identification was carried out by the full-automatic microbial identification instrument of French Merrier, and the relative numbers and chi-square test were mainly used for statistical analysis. Results 68.27% of 1784 strains were Gram-negative bacteria mainly from sputum(62.89%)and urine(11.49%), and most of them were Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae. 21.13% of 1784 strains were Gram-positive bacteria mainly from blood(30.77%)and urine(23.08%), and most of them were Staphylococcus aureus and Enterococcus faecalis. Among the same species of bacteria, the detection rate of multidrug-resistant Acinetobacter baumannii(MDR-AB)was 93.75% in the second year. Extensively drug resistant Acinetobacter baumannii(XDR-AB)had been preva- 山 东 大 学 学 报 (医 学 版)58卷2期 -孙艳婷,等. 新建医院ICU临床分离菌的分布及耐药变迁 \=-lent in April 2015. The average detection rate of ESBLs-producing Escherichia coli(ESBLs-EC), carbapenem-resistant Pseudomonas aeruginosa(CR-PA), methicillin-resistant Staphylococcus aureus(MRSA)and methicillin-resistant Coagulase-negative staphylococcus(MRCNS)were 68.31%, 53.48%, 60.55% and 86.87%, respectively. One strain of vancomycin-resistant Enterococcus faecalis was detected in 2014. Conclusion The new ICU should strengthen prevention of Acinetobacter baumannii colonization and epidemics. The drug resistance of isolates, especially non-fermenting Gram-negative bacilli, staphylococcus and enterococci, is significant in ICU. It is necessary to monitor drug resistance of MDR-AB, CR-PA, MRSA, MRCNS and ESBLs-EC, prevent nosocomial infection, and select rational antibiotics according to the prevalence of drug resistance.

Key words: New hospital, Intensive Care Unit, Clinical isolates, Resistance change

CLC Number: 

  • R378
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