Journal of Shandong University (Health Sciences) ›› 2018, Vol. 56 ›› Issue (7): 46-50.doi: 10.6040/j.issn.1671-7554.0.2018.141

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Applicability of Global Lung Function Initiative 2012 reference equations for spirometry to elderly Chinese in Jinan City

LIU Chunhong, TIAN Xinyu, WANG Dexiang, SHI Hui, XIAO Wei   

  1. Department of Pulmonary and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Published:2022-09-27

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Abstract: Objective To validate the applicability of Global Lung Function Initiative(GLI)-2012 reference values for spirometry to elderly Chinese in Jinan City. Methods Healthy people aged 60-84 without smoking history were recruited and underwent spirometry. FVC(forced vital capacity), FEV1(forced expiratory volume in one second),FEV1/FVC, and MMEF(maximal midexpiratory flow)were recorded. Z-scores were computed according to the GLI-2012 reference values. Comparisons of GLI-2012 predicted values and observed values, and lower limit of normal(LLN)computed using GLI-2012 and Zhongshan-2011 equations were performed by paired t test. Results A total of 438 subjects(228 females, 210 males)were completely qualified. The Z-scores of FVC, FEV1, FEV1/FVC and MMEF for males were 0.23±1.34, 0.27±1.31, 0.03±0.71, -0.03±0.94, and for females were 0.22±0.95, 0.08±0.89, -0.28±0.65, -0.14±0.90. The predicted mean values of GLI-2012 were in good agreement with observed values. However, the LLN of FEV1/FVC predicted by GLI-2012 equations was lower than that by Zhongshan-2011. The 95%CI of mean difference for males was(-5.79—-5.55)%(t=-91.310, P<0.001). The proportion of abnormal FEV1/FVC in the sample was 0.9% in terms of the GLI-2012 LLN, which was similar to the proportion when using(-overx)-3s as the cut off 山 东 大 学 学 报 (医 学 版)56卷7期 -刘春红,等. 全球肺功能倡议预计值对济南市老年人的适用性检验 \=-value(0.7%). Conclusion The GLI-2012 predicted mean values for spirometry are appropriate for the elderly in Jinan City, but it underestimates the LLN and may lead to the missed diagnosis of obstructive ventilatory defects.

Key words: Respiratory function tests, Spirometry, Reference values, Global Lung Function Initiative, Aged

CLC Number: 

  • R562
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