关键词: 胰岛素抵抗；脂联素；通径分析

Abstract:

Objective To explore the effect and style of adiponectin and other relative factors in insulin resistance (IR). Method  A total of 86 cases of IR and 87 non-IR subjects were enrolled in this study. Serum adiponectin and its relative factors including insulin, blood fasting glucose, body height, body weight, smoking, drinking and family history were investigated. Path analysis explored the effect of these factors in insulin resistance. Results  Path analysis showed that body mass index (BMI)， smoking index and adiponectin had direct effects on IR, however a family history of diabetes mellitus, gender, age and culture had indirect effects on IR by affecting BMI, adiponectin and smoking.  The results of path analysis indicated that the residual variation was on the high side, and the ability of explanation was only 14.07%. Conclusions  Adiponectin and other relative factors are not the most important ones on IR in the subjects.

Key words: Insulin resistance; Adiponectin; Path analysis