Abstract: Objective: To explore the effect of Cuyubanhenxiao on hypertrophic scars in rabbit ears. Methods: Twelve adult New Zealand white rabbits were given hypertrophic scars over the ventral surface of the right ears and were randomly divided into the Cuyubanhenxiao group (group A ) and the control group (group B). They were subjected to the drugs once every day for 1 month. The thickness of the scars was determined at the formation and at 4 weeks after treatment. Immunohistochemical (P53 and PCNA) and histomorphology were used to determine the scar tissues at 1 and 4 weeks. Results: The thickness of the scar was significantly different between the two groups (P＜0.05). Expression of p53 and PCNA was significantly different between the 1 week and 4 weeks groups (P＜0.05). Expression of p53 and PCNA was significantly different in group A between the 1 week and 4 weeks groups (P＜0.05), but there was no significant difference in group B between the 1 week and 4 weeks groups(P＞0.05). Conclusions: Cuyubanhenxiao can heal hypertrophic scars of rabbit ears, which may be caused by the decrease of the expression of p53 and PCNA.

Key words: Cuyubanhenxiao, Hypertrophic scar, Rabbits