NSCLC细胞周期素D1和p27异常表达与化疗敏感性及预后的相关性研究

山东大学学报(医学版)

NSCLC细胞周期素D1和p27异常表达与化疗敏感性及预后的相关性研究

李蓓，张磊，王卉，郝静，扈东艳，李明，王秀问

1 山东大学齐鲁医院化疗科，山东济南 250012； 2山东大学第二医院泌尿外科，山东济南 250033；3 山东省肿瘤医院放疗科，山东济南 250117

收稿日期:2005-10-29 修回日期:1900-01-01 出版日期:2006-09-24 发布日期:2006-09-24
通讯作者: 李蓓

Correlation between chemosensitivity and prognosis andabnormal expression of cyclin D1 and p27 in

LI Bei,ZHANG Lei,WANG Hui,HAO Jing,HU Dong-yan, LI Ming, WANG Xiu-wen

1. Department of Chemotherapy, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;2. Department of Urology, Second Hospital of Shandong University, Jinan 250033, Shandong, China;

Received:2005-10-29 Revised:1900-01-01 Online:2006-09-24 Published:2006-09-24
Contact: LI Bei

摘要/Abstract

摘要： 目的：研究细胞周期素D1(cyclin D1)和p27在非小细胞肺癌（NSCLC）中的表达与化疗敏感性及预后的关系，评价其表达在NSCLC中的临床价值。方法：应用SP方法检测了37例原发性NSCLC石蜡切片中cyclin D1和p27的表达。结果：37例NSCLC患者中，cyclin D1阳性表达者21例（56.76％），其表达和NSCLC患者的化疗疗效和预后显著相关(P＜0.05)。p27阳性表达率为32.43%(12/37)，其表达与NSCLC患者的化疗疗效无相关性(P＞0.05)，与患者的生存期显著相关(P＜0.05)。多因素分析表明，cyclin D1可作为NSCLC的独立预后因素。结论：NSCLC中cyclin D1的表达可作为预测化疗疗效和预后的指标；p27的表达可作为NSCLC的预后因素。

Abstract: To prognose the chemosensitivity and the survival in terms of the expression levels of cyclin D1 and p27 protein in nonsmall cell lung cancer(NSCLC). Method: Enhanced immunohistochemical staining(SP) technique was used to detect the expression of cyclin D1 and p27 protein in 37 cases of primary NSCLC specimens paraffinembedded. Results:Of the 37 NSCLC cases, positive cyclin D1 was found in 21(56.76％), and there were significant correlation between response to chemotherapy, survival and the expression of cyclin D1(P＜0.05). The positive expression rate of p27 protein was 32.43%(12/37), and there were no significant relationship between the expression of p27 and response to chemotherapy(P＞0.05). The expression of p27 was significantly associated with the survival of NSCLC. Multivariate analysis showed that cyclin D1 was a good prognostic factor in NSCLC. Conclusion: Expression of cyclin D1 may be a good prognostic factor for chemosensitivity and survival in NSCLC. Furthermore, the expression of p27 may play a prognostic role in NSCLC.

Key words: Lung carcinoma, Chemotherapy, Cyclins, Prognosis

李蓓,张磊,王卉,郝静,扈东艳,李明,王秀问. NSCLC细胞周期素D1和p27异常表达与化疗敏感性及预后的相关性研究[J]. 山东大学学报(医学版), 2006, 44(9): 963-965.

LI Bei,ZHANG Lei,WANG Hui,HAO Jing,HU Dong-yan,LI Ming,WANG Xiu-wen. Correlation between chemosensitivity and prognosis andabnormal expression of cyclin D1 and p27 in[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(9): 963-965.

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