探讨水蛭微粉对急性脑梗塞患者的临床治疗作用及机理

山东大学学报(医学版)

探讨水蛭微粉对急性脑梗塞患者的临床治疗作用及机理

郑国玲¹,张文高²,吴玉生¹,郑广娟

1．山东大学西区医院内科，山东济南 250012； 2．山东中医药大学基础医学院内科学教学研究室，山东　济南　250014

收稿日期:2005-09-14 修回日期:1900-01-01 出版日期:2006-09-24 发布日期:2006-09-24
通讯作者: 郑国玲

Effect of vWF, GMP140 of ultrafine particle of leeches in treating

ZHENG Guo-ing,WU Yu-sheng,ZHANG Wen-gao，ZHENG Guang-juan

１． Department of Internal Medicine, Western Hospital of Shandong University, Jinan 250012,Shandong, China； 2． Medical Teaching Research Center， Shandong University of Traditional Chinese Medicine Jinan 250014, Shandong, China

Received:2005-09-14 Revised:1900-01-01 Online:2006-09-24 Published:2006-09-24

摘要/Abstract

摘要： 目的：探讨水蛭微粉对急性脑梗塞患者的临床治疗作用及机理。方法：63例脑梗塞患者（病程在3?d以内）随机分为3组。A组（对照组）：21例，常规西药治疗；B组（粗粉组）：21例，常规西药加水蛭粗粉治疗；C组（微粉组）：21例，常规西药加水蛭微粉治疗。观察脑梗塞患者的临床治疗效果，治疗前后的血液血管性假血友病因子（vWF），血小板α颗粒膜蛋白140（GMP140、CD62p）水平。结果：两种水蛭制剂均能提高脑梗塞患者临床疗效，以微粉组疗效明显，总有效率比较：B组优于A组，P<0.05；C组优于A组，P<0.01。愈显率比较：C组优于B组，P<0.05。3组患者上述两项实验指标治疗后也均有改善，两水蛭组优于对照组，P＜0.01，C组优于B组，P＜0.01。结论：水蛭微粉较水蛭粗粉更能有效地提高脑梗塞患者的临床疗效，更能有效地抑制血管内皮损伤、血小板活化。

Abstract: To estimate the value of ultrafine particle of Leeches on acute brain infarction disease. Methods: A total of 63 cases of early brain infarction disease were divided into 3 groups： group A，treated with normal medicine； group B， treated with normal medicine and bigger particle of Leeches；group C ， treated with normal medicine and ultrafine particle of Leeches. The clinical symptom before and after treatment was observed, and also the level of blood Von Wille brand factor(vWF), pselection(GMP140) were observed. Results: The total response rate of group C and B was higher than that of group A(P<0.01, 0.05). The curative and marked response rates of group C were higher than those of group B(P<0.05). The improvement of blood vWF, GMP140 of group C was better than that of group B(P<0.05,0.01); and that of group B was better than group A(P<0.05, 0.01). Conclusion: There are serious vascular endothelium injury, platelet activity in both brain infarction patients. Ultrafine particle of Leeches is more effective in treating brain infarction disease than bigger particle of Leeches, and it is more effective in improving the blood levels of vWF, GMP140.

Key words: Brain infarction, Leeches, Von Wille brand factor, pselection

郑国玲,张文高,吴玉生,郑广娟. 探讨水蛭微粉对急性脑梗塞患者的临床治疗作用及机理[J]. 山东大学学报(医学版), 2006, 44(9): 960-962.

ZHENG Guo-ing,WU Yu-sheng,ZHANG Wen-gao,ZHENG Guang-juan. Effect of vWF, GMP140 of ultrafine particle of leeches in treating[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(9): 960-962.

参考文献

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed