功能食品对酒精性心肌病防护作用的研究进展

doi:10.6040/j.issn.1671-7554.0.2024.0397

摘要/Abstract

摘要： 酒精对心血管系统有多重影响,长期过量饮酒会引起明显的心脏毒性效应,引发酒精性心肌病,甚至猝死。近年来营养功能食品防治心血管疾病越来越得到大家的关注和认可。本文通过对酒精性心肌病的主要发病机制和营养功能食品防护酒精性心肌病的相关研究进展进行阐述和归纳总结,旨在为进一步探索酒精性心肌病的临床治疗策略以及开发新型功能食品提供参考。

关键词: 酒精性心肌病, 心肌损伤, 营养功能食品, 功能因子, 防护作用

Abstract: Alcohol has many effects on the cardiovascular system. Long-term excessive alcohol consumption has significant cardiotoxic effects, leading to alcoholic cardiomyopathy and even sudden death. The prevention and treatment of cardiovascular disease with functional foods has received increasing attention and recognition in recent years. This article elaborates and summarises the main pathogenesis of alcoholic cardiomyopathy and the relevant research progress on the protection of alcoholic cardiomyopathy by functional foods, with the aim of providing a reference for further exploration of clinical treatment strategies for alcoholic cardiomyopathy and development of new functional foods.

Key words: Alcoholic cardiomyopathy, Myocardial injury, Nutritional functional foods, Functional factors, Protective effects

中图分类号:

R541.9

孟妍,张晨一,刘峰,陈立勇. 功能食品对酒精性心肌病防护作用的研究进展[J]. 山东大学学报 (医学版), 2024, 62(8): 27-33.

MENG Yan, ZHANG Chenyi, LIU Feng, CHEN Liyong. Research progress on the protective effect of functional foods on alcoholic cardiomyopathy[J]. Journal of Shandong University (Health Sciences), 2024, 62(8): 27-33.

参考文献

[1] Fernández-Solà J. The effects of ethanol on the heart: alcoholic cardiomyopathy[J]. Nutrients, 2020, 12(2): 572. doi:10.3390/nu12020572.
[2] Dai J, Mukamal KJ, Krasnow RE, et al. Higher usual alcohol consumption was associated with a lower 41-y mortality risk from coronary artery disease in men independent of genetic and common environmental factors: the prospective NHLBI Twin Study[J]. Am J Clin Nutr, 2015, 102(1): 31-39.
[3] Maisch B. Alcoholic cardiomyopathy: the result of dosage and individual predisposition[J]. Herz, 2016, 41(6): 484-493.
[4] Larsson SC, Wallin A, Wolk A. Alcohol consumption and risk of heart failure: Meta-analysis of 13 prospective studies[J]. Clin Nutr, 2018, 37(4): 1247-1251.
[5] Steiner JL, Lang CH. Etiology of alcoholic cardiomyopathy: Mitochondria, oxidative stress and apoptosis[J]. Int J Biochem Cell Biol, 2017, 89: 125-135. doi:10.1016/j.biocel.2017.06.009.
[6] Maiuolo J, Maretta A, Gliozzi M, et al. Ethanol-induced cardiomyocyte toxicity implicit autophagy and NFkB transcription factor[J]. Pharmacol Res, 2018, 133: 141-150. doi:10.1016/j.phrs.2018.04.004.
[7] 代畅. 铁死亡对酒精性心肌损伤及相关心房颤动的影响及机制研究[D]. 武汉: 武汉大学, 2022.
[8] Guo XP, Chen M, Zeng HM, et al. Quercetin attenuates ethanol-induced iron uptake and myocardial injury by regulating the angiotensin II-L-type calcium channel[J]. Mol Nutr Food Res, 2018, 62(5): 10. doi:10.1002/mnfr.201700772.
[9] Liu XC, Zhang DA, Dong XR, et al. Pharmacological activation of CB2 receptor protects against ethanol-induced myocardial injury related to RIP1/RIP3/MLKL-mediated necroptosis[J]. Mol Cell Biochem, 2020, 474(1/2): 1-14.
[10] 徐贵发, 蔺新英. 功能食品与功能因子[M]. 济南: 山东大学出版社, 2005.
[11] 谢华宁, 郭宏, 刘正. B族维生素在酒精性心肌病发病中的作用[J]. 中华实用诊断与治疗杂志, 2017, 31(1): 19-22. XIE Huaning, GUO Hong, LIU Zheng. Role of B vitamins in alcoholic cardiomyopathy[J]. Journal of Chinese Practical Diagnosis and Therapy, 2017, 31(1): 19-22.
[12] Satish OS, Shaik SA. Thiamine mediated reversal of left ventricular dysfunction in patients with alcoholic cardiomyopathy[J]. Indian Heart J, 2021, 73(3): 389-391.
[13] Popova TA, Khusainova GK, Prokofiev II, et al. Correction of alcohol-induced damage to mitochondria in cardiac and cerebral cells by derivatives of neuroactive amino acids[J]. Bull Exp Biol Med, 2020, 169(2): 218-223.
[14] Perfilova VN, Kustova MV, Popova TA, et al. Cardioprotective effects of a new glutamic acid derivative in chronic alcohol intoxication[J]. Alcohol, 2021, 93: 1-10. doi:10.1016/j.alcohol.2021.01.006.
[15] Yao Z, Zhang YL, Li HY, et al. Synergistic effect of Se-methylselenocysteine and vitamin E in ameliorating the acute ethanol-induced oxidative damage in rat[J]. J Trace Elem Med Biol, 2015, 29: 182-187. doi:10.1016/j.jtemb.2014.08.004.
[16] Shirpoor A, Nemati S, Ansari MH, et al. The protective effect of vitamin E against prenatal and early postnatal ethanol treatment-induced heart abnormality in rats: a 3-month follow-up study[J]. Int Immunopharmacol, 2015, 26(1): 72-79. doi:10.1016/j.intimp.2015.03.008.
[17] Simplicio JA, Hipólito UV, Vale GT, et al. Acute ethanol intake induces NAD(P)H oxidase activation and rhoa translocation in resistance arteries[J]. Arq Bras Cardiol, 2016, 107(5): 427-436. doi:10.5935/abc.20160147.
[18] 刘昕皓, 魏粉菊, 王学顺, 等. 多酚类化合物的生物活性研究进展[J]. 中国医药工业杂志, 2021, 52(4): 471-483. LIU Xinhao, WEI Fenju, WANG Xueshun, et al. Progress on biological activities of polyphenols[J]. Chinese Journal of Pharmaceuticals, 2021, 52(4): 471-483.
[19] Tu S, Cao FT, Fan XC, et al. Resveratrol protects the loss of connexin 43 induced by ethanol exposure in neonatal mouse cardiomyocytes[J]. Naunyn Schmiedebergs Arch Pharmacol, 2017, 390(6): 651-660.
[20] Yu LM, Dong X, Li N, et al. Polydatin attenuates chronic alcohol consumption-induced cardiomyopathy through a SIRT6-dependent mechanism[J]. Food Funct, 2022, 13(13): 7302-7319.
[21] 张航. 姜黄素对乙醇作用下内质网应激介导的心肌细胞胰岛素抵抗的影响[D]. 沈阳: 中国医科大学, 2018.
[22] Gaballah HH, Ghanem HB, Tahoon NM, et al. Hesperidin promotes lysosomal biogenesis in chronically ethanol-induced cardiotoxicity in rats: a proposed mechanisms of protection[J]. J Biochem Mol Toxicol, 2019, 33(3): e22253. doi:10.1002/jbt.22253.
[23] Pinto C, Cestero JJ, Rodríguez-Galdón B, et al. Xanthohumol, a prenylated flavonoid from hops(Humulus lupulus L.), protects rat tissues against oxidative damage after acute ethanol administration[J]. Toxicol Rep, 2014, 1: 726-733. doi:10.1016/j.toxrep.2014.09.004.
[24] 何琼, 廖应英, 干艳捷, 等. 葛根素注射液对酒精性心肌病患者心功能的影响[J]. 现代中西医结合杂志, 2012, 21(13): 1410-1411. HE Qiong, LIAO Yingying, GAN Yanjie, et al. Effect of puerarin injection on cardiac function in patients with alcoholic cardiomyopathy[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2012, 21(13): 1410-1411.
[25] 周琳, 梁轩铭, 赵磊. 天然类胡萝卜素的生物合成研究进展[J]. 生物技术通报, 2022, 38(7): 119-127. ZHOU Lin, LIANG Xuanming, ZHAO Lei. Biosynthesis of natural carotenoids: progress and perspective[J]. Biotechnology Bulletin, 2022, 38(7): 119-127.
[26] Fan CD, Sun JY, Fu XT, et al. Astaxanthin attenuates homocysteine-induced cardiotoxicity in vitro and in vivo by inhibiting mitochondrial dysfunction and oxidative damage[J]. Front Physiol, 2017, 8: 1041. doi:10.3389/fphys.2017.01041.
[27] Zhang KL, Zhuo HL, Guo JY, et al. Astaxanthin alleviates the process of cardiac hypertrophy by targeting the METTL3/Circ_0078450/MiR-338-3p/GATA4 pathway[J]. Int Heart J, 2024, 65(1): 119-127.
[28] Wang WH, Liu TH, Liu YY, et al. Astaxanthin attenuates alcoholic cardiomyopathy via inhibition of endoplasmic reticulum stress-mediated cardiac apoptosis[J]. Toxicol Appl Pharmacol, 2021, 412: 115378. doi:10.1016/j.taap.2020.115378.
[29] 刘江梅. 32种人参皂苷抑制肝癌细胞HepG2和SMMC7721增殖作用的构效关系[D]. 南昌: 南昌大学, 2021.
[30] 王晓琴, 杜艳伟, 闻乃研, 等. 人参二醇组皂苷对家兔急性酒精性心肌损伤的保护作用及其机制[J]. 吉林大学学报(医学版), 2014, 40(3): 471-475. WANG Xiaoqin, DU Yanwei, WEN Naiyan, et al. Protective effect of Panaxadiol Saponins on acute alcohol myocardial inj ury in rabbits and mechanism[J]. Journal of Jilin University(Medicine Edition), 2014, 40(3): 471-475.
[31] 耿佳欢. 多汁乳菇多糖结构分析及生物活性研究[D]. 广州: 华南理工大学, 2019.
[32] 龚燕思, 林菲菲, 黄仁鸿等. 多汁乳菇对糖尿病小鼠血糖的影响[J]. 中国临床药理学杂志, 2019, 35(18): 2068-2070. GONG Yansi, LIN Feifei, HUANG Renhong, et al. Hypoglycemic effects of Lactarius volemus Fr. in diabetic mice [J]. The Chinese Journal of Clinical Pharmacology, 2019, 35(18): 2068-2070.
[33] 冉靓, 张桂玲, 李素莲, 等. 黔产多汁乳菇多糖脱色工艺及抗氧化活性研究[J]. 食品工业, 2019, 40(1): 108-111. RAN Jing, ZHANG Guiling, LI Sulian, et al. Decolorization process and antioxidant activity of polysaccharide from Lactarius volemus in Guizhou[J]. The Food Industry, 2019, 40(1): 108-111.
[34] 王秋艳, 黄馨阅, 曾晶, 等. 多汁乳菇多糖对酒精性损伤小鼠心脏及肾脏的抗氧化作用[J]. 安徽农业大学学报, 2022, 49(2): 338-343. WANG Qiuyan, HUANG Xinyue, ZENG Jing, et al. Antioxidant effect of polysaccharides from Lactaruis volemus Fr.on heart and kidney of mice with alcoholic injury[J]. Journal of Anhui Agricultural University, 2022, 49(2): 338-343.
[35] 朱瑞芳, 吕亚茹, 张珺,等. 功能食品在慢性病防治中的应用及带动区域经济增长的影响因素分析[J]. 全科护理, 2022, 20(33): 4666-4671. ZHU Ruifang, LYU Yaru, ZHANG Jun, et al. Application of functional food in the prevention and treatment of chronic diseases and its influencing factors on regional economic growth [J]. Chinese General Practice Nursing, 2022, 20(33): 4666-4671.
[36] 张译敏, 廖秀玲, 王雪妮,等. 五味子乙素抗炎作用研究进展[J]. 中成药, 2022, 44(10): 3244-3248.
[37] Tao Y, Zhou H, Hang L, et al. Schisandrin B Protects against Acute Ethanol-Induced Cardiac Injury by Downregulating Autophagy via the NOX4/ROS Pathway [J]. Pharmacology, 2021, 106(3-4): 177-188.
[38] Li ZM, Xu SW, Liu PQ. Salvia miltiorrhiza Burge(Danshen): a golden herbal medicine in cardiovascular therapeutics[J]. Acta Pharmacol Sin, 2018, 39(5): 802-824.
[39] Deng HY, Yu B, Li Y. Tanshinone IIA alleviates acute ethanol-induced myocardial apoptosis mainly through inhibiting the expression of PDCD4 and activating the PI3K/Akt pathway[J]. Phytother Res, 2021, 35(8): 4309-4323.
[40] 王树明, 陈曦, 孙琦,等. 中药材黄芪药理作用的相关研究进展[J]. 感染、炎症、修复, 2022, 23(4): 236-239.
[41] 刘向飞. 中西医结合治疗酒精性心肌病的效果分析[J]. 中西医结合心血管病电子杂志, 2016, 4(9): 193-193.
[42] Zdrojewicz Z, Kosowski W, Królikowska N, et al. Betel-the fourth most popular substance in the world[J]. Pol Merkur Lekarski, 2015, 39(231): 181-185.
[43] 杨靖涌. 槟榔碱对SD大鼠急性酒精中毒后血清SOD含量及心肌损伤的影响[D]. 衡阳: 南华大学, 2020.
[44] Xu XM, Yi H, Wu JS, et al. Therapeutic effect of berberine on metabolic diseases: both pharmacological data and clinical evidence[J]. Biomedecine Pharmacother, 2021, 133: 110984. doi:10.1016/j.biopha.2020.110984.
[45] Cai Y, Xin QQ, Lu JJ, et al. A new therapeutic candidate for cardiovascular diseases: berberine[J]. Front Pharmacol, 2021, 12: 631100. doi:10.3389/fphar.2021.631100.
[46] 杨慧, 朱俐俐. 小檗碱对早期ACM大鼠治疗效果及机制的研究[J]. 湖南师范大学学报(医学版), 2013, 10(1): 40-44. YANG Hui, ZHU Lili. The effect of the intervention of berberine in ACM rats[J]. Journal of Hunan Normal University(Medical Sciences), 2013, 10(1): 40-44.
[47] 刘慧. 不同剂量小檗碱对酒精性心肌损伤大鼠的保护作用研究[D]. 长沙: 湖南师范大学, 2014.
[48] Shirpoor A, Zerehpoosh M, Ansari MHK, et al. Ginger extract mitigates ethanol-induced changes of alpha and beta- myosin heavy chain isoforms gene expression and oxidative stress in the heart of male wistar rats[J]. DNA Repair, 2017, 57: 45-49. doi:10.1016/j.dnarep.2017.06.023.
[49] 王金忠. 辅酶Q10联合曲美他嗪治疗老年酒精性心肌病心力衰竭的疗效观察[J]. 中国社区医师, 2015, 31(4): 24-25. WANG Jinzhong. The curative effect observation of coenzyme Q10 combined with trimetazidine in the treatment of heart failure of the old alcoholic cardiomyopathy[J]. Chinese Community Doctors, 2015, 31(4): 24-25.
[50] 林世东, 张燕, 蔡兆斌. 曲美他嗪联合泛醌对酒精性心肌病患者心室功能及运动耐量的影响[J]. 中国医药导报, 2016, 13(35): 127-130. LIN Shidong, ZHANG Yan, CAI Zhaobin. Influence of Trimetazidine combined with Ubiquinone on ventricular function and exercise tolerance in patients with alcoholic cardiomyopathy[J]. China Medical Herald, 2016, 13(35): 127-130.
[51] 曲航, 高鑫, 伊娟娟, 等. 食源性天然产物对酒精性肝损伤的防护作用研究进展[J]. 食品科学, 2020, 41(17): 283-290. QU Hang, GAO Xin, YI Juanjuan, et al. Review on the protective effects of food-derived natural compounds on alcohol-induced liver injury[J]. Food Science, 2020, 41(17): 283-290.

多维度评价

Viewed

Full text

226

HTML			PDF

Just accepted	Online first	Issue	Just accepted	Online first	Issue
0	0	0	0	0	226

From	Others	local

Times	6	220
Rate	3%	97%

Abstract

288

Just accepted	Online first	Issue

0	0	288

From	Others	local

Times	286	2
Rate	99%	1%

Cited

Web of Science	Crossref	ScienceDirect	Search for Citations in Google Scholar >>


This page requires you have already subscribed to WoS.

Shared

Discussed