氮氧化物抗紫外线所致豚鼠皮肤光损伤的病理研究

山东大学学报(医学版)

氮氧化物抗紫外线所致豚鼠皮肤光损伤的病理研究

陈宏泉¹,王国英²,李春阳¹,王桂芝²,吴延芳²

1. 山东大学齐鲁医院皮肤科, 山东济南 250012;2. 青岛大学医学院附属医院皮肤科, 山东青岛 266003

收稿日期:2005-10-25 修回日期:1900-01-01 发布日期:2006-06-25
通讯作者: 陈宏泉

CHEN Hong-quan¹,WANG Guo-ying²,WANG Gui-zhi²,WU Yan-fang²,LI Chun-yang¹

1. Department of Dermatology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;2. Department of Dermatology, Affiliated Hospital of Medical School of Qingdao University,Qingdao 266003, Shandong, China

Received:2005-10-25 Revised:1900-01-01 Published:2006-06-25

摘要/Abstract

摘要： 目的：从病理学角度探讨氮氧化物Tempol对紫外线所致豚鼠皮肤光损伤的防护作用。方法：36只豚鼠随机分成非照射对照组、照射对照组、Tempol组，除非照射对照组外，其余两组接受紫外线照射共14周。结果：照射对照组豚鼠真皮胶原纤维及弹力纤维增粗、断裂、排列紊乱，同时其皮肤丙二醛含量明显高于非照射对照组和Tempol组(P均＜0.01)。结论：Tempol对紫外线引起的皮肤光损伤具有保护作用。

Abstract: To investigate the protective effects of Tempol（a nitroxide）on skin photodamage caused by ultraviolet in guinea pigs from the view of pathology. Methods: A total of 36 guinea pigs were divided into 3 groups randomly: nonradiation control, radiation control and Tempol . Except for nonradiation control, other two groups were monitored following radiation with ultraviolet for 14 weeks. Results: The collagen and elastic fibers became thicker，fragmented and disarranged in radiation control group．And the MDA content in radiation control group was significantly higher than in nonradiation and Tempol groups at the same time (P＜0.01). Conclusion: Tempol has a protective effect on skin photodamage caused by ultraviolet.

Key words: Nitroxide, Ultraviolet, Photodamage, Guinea pigs

陈宏泉,王国英,李春阳,王桂芝,吴延芳 . 氮氧化物抗紫外线所致豚鼠皮肤光损伤的病理研究[J]. 山东大学学报(医学版), 2006, 44(6): 638-640.

CHEN Hong-quan,WANG Guo-ying,WANG Gui-zhi,WU Yan-fang,LI Chun-yang. [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(6): 638-640.

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