人源性长寿保障基因2在结直肠癌组织中的表达及其临床意义

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doi:10.6040/j.issn.1671-7554.0.2019.180

摘要： 目的探讨人源性长寿保障基因2(LASS2)在结直肠癌组织中的表达及其临床意义。方法选取2011年8月至2013年8月结直肠癌患者85例,免疫组化(SP法)检测结直肠癌和癌旁组织中LASS2蛋白表达,术后随访,随访截止日期为2018年8月30日,78例患者得到完整随访,随访率91.76%。生存分析采用Kaplan-Meier法和Log-rank检验,患者预后的影响因素分析采用Cox比例风险回归模型。结果 LASS2蛋白在结直肠癌组织中阳性表达率(32.94% vs 78.82%,P<0.001)低于癌旁组织。LASS2蛋白在中低分化、TNM分期Ⅲ+Ⅳ期和发生淋巴结转移的结直肠癌组织中阳性表达率低于高分化、TNM分期Ⅰ+Ⅱ期和未发生淋巴结转移的结直肠癌组织(P<0.05);LASS2蛋白阳性表达组患者总生存时间(57.60个月 vs 28.47个月, P<0.001)及累积生存率(55.60% vs 19.60%,P<0.001)高于LASS2蛋白阴性表达组。分化程度、TNM分期、淋巴结转移和LASS2蛋白表达是影响结直肠癌患者预后的风险因素(HR=0.134、2.907、2.478、0.476,P<0.05)。结论 LASS2蛋白在结直肠癌患者组织中呈低表达,且与患者恶性化进展及预后有关,可能是结直肠癌患者预后评估的潜在生物标志物。

关键词: 结直肠癌, 人源性长寿保障基因2, 预后, Cox比例风险回归模型

Abstract: Objective To investigate the expression and clinical significance of homo sapiens longevity assurance homologue 2 of yeast LAG1(LASS2)in colorectal cancer. Methods A total of colorectal cancer 85 cases treated during Aug. 2011 and Aug. 2013 were involved. The protein expression of LASS2 in colorectal cancer and adjacent tissues were detected with immunohistochemistry(SP method). All patients were followed up, and until Aug. 30, 2018, the complete follow-up data of 78(91.76%)cases were obtained. Patients’ survival was analyzed using Kaplan-Meier method and Log-rank test. The influencing factors on prognosis were determined with Cox proportional hazards regression model. Results The positive expression rates of LASS2 in colorectal cancer tissues and adjacent tissues was 32.94% vs 78.82%(P<0.001). The positive expression rates of LASS2 in colorectal cancer tissues with moderately poor differentiation, TNM stage Ⅲ+Ⅳ and lymph node metastasis were lower than that in high differentiation, TNM stage Ⅰ+Ⅱ and without lymph node metastasis(P<0.05). The overall survival of patients with positive versus negative LASS2 expression was 57.60 vs 28.47 months(P<0.001), and cumulative survival rate was 55.60% vs 19.60%(P<0.001). The differentiation, TNM stage, lymph node metastasis and protein expression of LASS2 were influencing factors on the 山东大学学报 (医学版)57卷7期 -郭艳,等.人源性长寿保障基因2在结直肠癌组织中的表达及其临床意义 \=-prognosis(HR=0.134, 2.907, 2.478 and 0.476, P<0.05). Conclusion LASS2 is lowly expressed in colorectal cancer tissues, and is related to the malignant progression and prognosis. It might be a potential biomarker for prognosis assessment.

Key words: Colorectal cancer, Homo sapiens longevity assurance homologue 2 of yeast LAG1, Prognosis, Cox proportional hazard regression model

中图分类号:

R735.3

郭艳,张哲莹,王云溪,魏小娟. 人源性长寿保障基因2在结直肠癌组织中的表达及其临床意义[J]. 山东大学学报 (医学版), 2019, 57(7): 67-71.

8.GUO Yan, ZHANG Zheying, WANG Yunxi, WEI Xiaojuan. Expression and clinical significance of homo sapiens longevity assurance homologue 2 of yeast LAG1 in colorectal cancer[J]. Journal of Shandong University (Health Sciences), 2019, 57(7): 67-71.

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