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山东大学学报 (医学版) ›› 2019, Vol. 57 ›› Issue (3): 58-62.doi: 10.6040/j.issn.1671-7554.0.2018.1411

• • 上一篇    

西格列汀在糖尿病周围神经病变中的效果

刘萍,庄向华,徐敏,张亮,王雪萌,尚攀,郑凤杰,陈诗鸿   

  1. 山东大学第二医院内分泌科, 山东 济南 250012)〓
  • 发布日期:2022-09-27
  • 通讯作者: 陈诗鸿. E-mail:chenshihong26@163.com
  • 基金资助:
    国家自然科学基金(81670753,81800722);2018年度山东省重点研发计划(公益类专项)项目立项(2018GSF118108);山东省医药卫生科技发展计划(2014WS0156)

Effect of sitagliptin in diabetic peripheral neuropathy

LIU Ping, ZHUANG Xianghua, XU Min, ZHANG Liang, WANG Xuemeng, SHANG Pan, ZHENG Fengjie, CHEN Shihong   

  1. Department of Endocrinology, The Second Hospital of Shandong University, Jinan 250012, Shandong, China
  • Published:2022-09-27

摘要: 目的 探讨西格列汀在糖尿病周围神经病变(DPN)中的治疗效果。 方法 选取DPN患者36例,给予西格列汀治疗6个月。比较治疗前后血糖、血脂、多伦多临床评分系统(TCSS)评分及神经传导速度(NCV)变化情况。 结果 应用西格列汀治疗24周后,DPN患者空腹血糖及餐后2 h血糖水平下降(P<0.01),糖化血红蛋白水平降低(P<0.001),TCSS评分下降(P<0.001),NCV增加(P<0.001)结论 西格列汀治疗可改善DPN患者临床症状及NCV,在DPN的治疗中具有良好的应用价值。

关键词: 糖尿病周围神经病变, 西格列汀, 二肽基肽酶Ⅳ抑制剂, 多伦多临床评分系统评分, 神经传导速度

中图分类号: 

  • R587.2
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