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山东大学学报 (医学版) ›› 2021, Vol. 59 ›› Issue (6): 111-116.doi: 10.6040/j.issn.1671-7554.0.2020.1702

• 临床医学 • 上一篇    下一篇

微生态制剂肠内营养对43例重型颅脑损伤患者的疗效

章露文,范锐心,常颖,张晴   

  1. 郑州人民医院营养科, 河南 郑州 450052
  • 发布日期:2021-06-10
  • 通讯作者: 章露文. E-mail:dandan0318_6@163.com
  • 基金资助:
    河南省重点研发与推广专项(182102310408);河南省卫生健康委省部共建青年项目(SB201902021)

Effect of microecological enteral nutrition in 43 patients with severe craniocerebral injury

ZHANG Luwen, FAN Ruixin, CHANG Ying, ZHANG Qing   

  1. Department of Nutrition, Peoples Hospital of Zhengzhou, Zhengzhou 450052, Henan, China
  • Published:2021-06-10

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摘要： 目的 探讨微生态制剂肠内营养支持在重型颅脑损伤患者中的应用疗效。 方法 选取2018年5月至2020年6月于郑州人民医院治疗的重型颅脑损伤患者85例,其中对照组42例(常规肠内营养组)和实验组43例(微生态制剂肠内营养组)。比较两组患者治疗前后基本情况、营养状态、免疫功能指标及胃肠功能并发症。 结果 治疗前两组患者基本情况无差异,治疗后两组患者TP、Hb、PA、ALB、GLO、IgA、IgM及IgG数值均升高,实验组效果优于对照组,差异有统计学意义(P均<0.05);治疗后两组患者CD4+数值升高、CD8+数值降低,胃肠道并发症腹胀、呕吐及误吸发生率差异均无统计学意义(P均>0.05);实验组患者腹泻发生率低于对照组,差异有统计学意义(P=0.031);Logistic回归分析结果显示,ALB、PA、IgG和腹泻与患者微生态制剂肠内营养治疗效果有关。 结论 重型颅脑损伤患者术后行微生态制剂肠内营养治疗可以改善营养状况和免疫功能。

关键词: 重型颅脑损伤, 微生态制剂, 肠内营养支持

Abstract: Objective To investigate the effect of microecological enteral nutrition on patients with severe craniocerebral injury. Methods Eighty-five patients with severe craniocerebral injury treated in Peoples Hospital of Zhengzhou from May 2018 to June 2020 were selected and divided into control group(conventional enteral nutrition group, n= 42)and experimental group(probiotics enteral nutrition group, n= 43). The basic condition, nutritional indexes, immune function indexes and gastrointestinal complications were compared between the two groups. Results There was no significant difference in the basic condition between the two groups before treatment. However, after treatment, the values of TP, Hb, ALB, PA, GLO, IgA, IgM and IgG were increased in both groups, and the corresponding levels in the experimental group were higher than those in the control group(all P<0.05); the value of CD4+ increased while that of CD8+ decreased, and the incidence of gastrointestinal complications such as abdominal distension, vomiting and misinhalation showed no significant difference in either group(all P>0.05); the incidence of diarrhea in the experimental group was significantly lower than that in control group(P=0.031). Logistic regression analysis showed that ALB, PA, IgG and diarrhea were related to the effect of microecological enteral nutrition. Conclusion Microecological enteral nutrition can improve nutritional status and immune function in patients with severe craniocerebral injury.

Key words: Severe craniocerebral injury, Microecological preparation, Enteral nutrition

中图分类号: 

  • R651.15
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