原发性开角型青光眼患者与正常人黄斑区脉络膜厚度的比较

doi:10.6040/j.issn.1671-7554.0.2014.354

山东大学学报（医学版） ›› 2015, Vol. 53 ›› Issue (2): 71-74.doi: 10.6040/j.issn.1671-7554.0.2014.354

原发性开角型青光眼患者与正常人黄斑区脉络膜厚度的比较

张苗苗, 王建荣, 刘伟

济南市第二人民医院眼科, 山东济南 250001

收稿日期:2014-05-30 发布日期:2015-02-10
通讯作者: 张苗苗. E-mail:zmm_333@126.com E-mail:zmm_333@126.com

Comparison of macular choroidal thickness between primary open angle glaucoma and normal subjects

ZHANG Miaomiao, WANG Jianrong, LIU Wei

Department of Ophthalmology, The Second People's Hospital of Jinan, Jinan 250001, Shandong, China

Received:2014-05-30 Published:2015-02-10

摘要/Abstract

摘要： 目的研究原发性开角型青光眼(POAG)患者黄斑区脉络膜厚度与正常人之间的差异.方法应用增强深部成像的相干光断层扫描(EDI-OCT)仪测量60例(60只眼)POAG患者(POAG组)和60例(60只眼)正常人(对照组)黄斑区脉络膜厚度.组内相关系数(ICC)表示检测者内和检测者间信度分析.结果检测者内的ICC值为0.994～0.999(P<0.001),检测者间的ICC值为0.995～0.998(P<0.001).黄斑区脉络膜厚度特征为黄斑中心凹下方最厚,鼻侧最薄.POAG组黄斑区各象限脉络膜厚度均明显厚于对照组(t=3.114～4.456, P<0.05).POAG组和对照组黄斑区象限脉络膜厚度均随年龄增加及眼轴增长而变薄(r=-0.456～-0.520,-0.445～-0.491; P<0.05).结论 POAG患者的黄斑区脉络膜厚度比正常人厚;POAG患者黄斑区脉络膜增厚与青光眼的发病机制相关.

关键词: 脉络膜, 青光眼,开角型, 体层摄影术,光学相干

Abstract: Objective To compare the macular choroidal thickness between primary open angle glaucoma (POAG) and normal subjects using enhanced depth imaging optical coherence tomography (EDI-OCT). Methods Scans were performed by EDI-OCT in eyes of 60 POAG patients and 60 age-and sex-matched normal subjects. The reliability analysis of intra-and inter-observer was tested using intraclass correlation coefficient (ICC). Results The intra-and inter-observer ICC values ranged from 0.994 to 0.999 and 0.995 to 0.998 respectively (both P<0.001). In the COPD patients and controls, the choroidal thickness beneath the fovea was thickest and the nasal choroidal thickness was thinnest. Each quadrant of choroidal thickness in POAG patients were thicker than that of the controls (t=3.114 to 4.456, P<0.05). For both subjects investigated, the choroidal thickness showed a negative correlation with age and axial length (r=-0.456 to -0.520,-0.445 to -0.491; P<0.05). Conclusion The choroidal thickness of POAG patients is thicker than that of the controls, and the thickening choroidal thickness in POAG patients is associated with the pathogenesis of glaucoma.

Key words: Choroid, Glaucoma, open-angle, Tomography, optical coherence

中图分类号:

R775

张苗苗, 王建荣, 刘伟. 原发性开角型青光眼患者与正常人黄斑区脉络膜厚度的比较[J]. 山东大学学报（医学版）, 2015, 53(2): 71-74.

ZHANG Miaomiao, WANG Jianrong, LIU Wei. Comparison of macular choroidal thickness between primary open angle glaucoma and normal subjects[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(2): 71-74.

参考文献

[1] Yin ZQ, Vaegan, Millar TJ, et al. Widespread choroidal insufficiency in primary open—angle glaucoma[J]. J Glaucoma, 1997, 6(1):23-32.
[2] Spraul CW, Lang GE, Lang GK, et al. Morphometric changes of the chorioeapillaris and the choroidal vasculature in eyes with advanced glaucomatous changes[J]. Vision Res, 2002, 42(7):923-932.
[3] Galassi F, Sodi A, Ucci F, et al. Ocular hemodynamics and glaucoma prognosis:a color Doppler image study[J]. Arch Ophthalmol, 2003, 121(12):1711-1715.
[4] Grunwald JE, Piltz J, Hariprasad SM, et al. Optic nerve and choroidal circulation in glaucoma[J]. Invest Ophthalmol Vis Sei, 1998, 39(12):2329-2336.
[5] Nieolela MT, Hnik P, Drance SM. Scanning laser Doppler flowrneter study of retinal and optic disk blood flow in glaucomatous patients[J]. Am J Ophthalmol, 1996, 122(6):775-783.
[6] Mwanza JC, Hochberg JT, Banitt MR, et al. Lack of association between glaucoma and macular choroidal thickness measured with enhanced depth-imaging optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2011, 52(6):3430-3435.
[7] Spaide RF. Age-related choroidal atrophy[J]. Am J Ophthalmol, 2009, 147(5):801-810.
[8] Cennamo G, Finelli M, Iaccarino G, et al. Choroidal thickness in open-angle glaucoma measured by spectral-domain scanning laser ophthalmoscopy/optical coherence omography[J]. Ophthalmologica, 2012, 228(1):47-52.
[9] Zhou M, Wang W, Ding X, et al. Choroidal thickness in fellow eyes of patients with acute primary angle-closure measured by enhanced depth imaging spectral-domain optical coherence tomography[J]. Invest Ophthalmol Vis Sei, 2013, 54(3):1971-1978.
[10] Rosen ES, Boyd TA. New method of assessing choroidal ischemia in open-angle glaucoma and ocular hypertension[J]. Am J Ophthalmol, 1970, 70(6):912-921.
[11] Cristini G, Cennamo G, Daponte P. Choroidal thickness in primary glaucoma[J]. Ophthalmologica, 1991, 202(2):81-85.
[12] Ouyang Y, Heussen FM, Mokwa N, et al. Spatial distribution of posterior pole choroidal thickness by spectral domain optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2011, 52(9):7019-7026.
[13] Hirata M, Tsujikawa A, Matsumoto A, et al. Macular choroidal thickness and volume in normal subjects measured by sweptsource optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2011, 52(8):4971-4978.
[14] Maul EA, Friedman DS, Chang DS, et al. Choroidal thickness measured by spectral domain optical coherence tomography:factors affecting thickness in glaucoma patients[J]. Ophthalmology, 2011, 118(8):1571-1579.
[15] 王世明,尚颖萍,余腾,等.近视患者黄斑区脉络膜厚度及其影响因素分析[J]. 中华眼底病杂志, 2013, 29(5):457-460. WANG Shiming, SHANG Yingping, YU Teng. et al. Choroidal thickness and the correlation factor in myopic Chinese population[J]. Chinese Journal of Ocular Fundus Diseases, 2013, 29(5):457-460.

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原发性开角型青光眼患者与正常人黄斑区脉络膜厚度的比较

Comparison of macular choroidal thickness between primary open angle glaucoma and normal subjects

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