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山东大学学报(医学版) ›› 2013, Vol. 51 ›› Issue (10): 81-84.

• 临床医学 • 上一篇    下一篇

ERCC1及C-erbB2在子宫内膜癌组织中的表达及其对中西医结合疗效的影响

冯文1,房瑜1,杨成喜2   

  1. 江苏省连云港市第一人民医院 徐州医学院附属连云港医院 1.妇科; 2.肿瘤内科,  江苏 连云港 222002
  • 收稿日期:2012-08-30 出版日期:2013-10-10 发布日期:2013-10-10
  • 通讯作者: 杨成喜， E-mail:fengw125@126.com

Expressions of ERCC1 and C-erbB2 in endometrial carcinoma tissue and their impact on the therapeutic effect of integrated Chinese and Western medicine

FENG Wen1, FANG Yu1, YANG Cheng-xi2   

  1. 1. Department of Gynecology; 2. Department of Medical Oncology, the First People′s Hospital of Lianyungang,
    Lianyungang Hospital Affiliated to Xuzhou Medical College, Lianyungang 222002, Jiangsu, China
  • Received:2012-08-30 Online:2013-10-10 Published:2013-10-10

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摘要：

目的  探讨核苷酸切除修复交叉互补基因 (ERCC1)和人表皮生长因子(C-erbB2) 在子宫内膜癌组织中的表达及其对化疗联合舒肝益肾方疗效的影响。方法   将51例子宫内膜癌患者作为子宫内膜癌组，20例子宫内膜正常者为对照组。子宫内膜癌组给予化疗联合中药疏肝益肾方治疗。检测2组子宫内膜组织中ERCC1及C-erbB2表达，分析子宫内膜癌患者组织中C-erbB2、ERCC1表达对中西医结合治疗子宫内膜癌疗效的影响。结果  C-erbB2、ERCC1在子宫内膜癌组织中阳性表达随组织学分级增加而增强，G3级C-erbB2阳性率明显高于G1级和G2级（P＜0.05）；G3级的ERCC1阳性率明显高于G1级（P＜0.05）。C-erbB2、ERCC1在子宫内膜癌组中阳性表达率明显高于对照组（P＜0.05或P＜0.01）。子宫内膜癌组C-erbB2、ERCC1阳性表达者的中西医结合疗效明显低于C-erbB2、ERCC1阴性表达者（P＜0.05）。结论  ERCC1和C-erbB2表达状态有利于判断子宫内膜癌病理分级，并可用于疗效评估。

关键词: 子宫内膜癌; 核苷酸切除修复交叉互补基因; 癌基因人表皮生长因子; 舒肝益肾方

Abstract:

Objective  To investigate the expressions of nucleotide excision repair cross-complementing gene (ERCC1) and human epidermal growth factor (C-erbB2) in endometrial carcinoma tissue and their impact on the therapeutic effect of chemotherapy combined with liver-soothing kidney-tonifying formula. Methods  Fifty-one patients with endometrial cancer and 20 subjects with normal endometrium were respectively as endometrial carcinoma group and control group. The former was treated with chemotherapy combined with liver-soothing kidney-tonifying formula. The expressions of ERCC1 and C-erbB2 in endometrial tissue of two groups were detected, and the impact of C-erbB2 and ERCC1 expressions on the therapeutic effect of integrated Chinese and Western medicine was analyzed. Results  The positive expressions of C-erbB2 and ERCC1 in endometrial cancer tissue were increased with histological grading increasing. C-erbB2 positive rate at grade G3 was significantly higher than at grades G1 and G2 (P<0.05), and ERCC1 positive rate at grade G3 significantly higher than at grade G1 (P<0.05). Positive expression rates of C-erbB2 and ERCC1 in endometrial cancer group were significantly higher than in control group (P<0.05 or P<0.01). The therapeutic effect of integrated Chinese and Western medicine on patients with positive expressions of C-erbB2 and ERCC1 was significantly lower than that with negative ones (P<0.05). Conclusion  ERCC1 and C-erbB2 expressions are conducive to determining the pathological grading of endometrial carcinoma, and can be used to assess the therapeutic effect.

Key words: Endometrial cancer; Nucleotide excision repair cross-complementing gene; Oncogene human epidermal growth factor; Liver-soothing kidney-tonifying formula

中图分类号: 

  • R737.33
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