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山东大学学报(医学版) ›› 2013, Vol. 51 ›› Issue (06): 25-28.

• 基础医学 • 上一篇    下一篇

来曲唑在多囊卵巢综合征促排卵中的应用

王玮1,滑天2,曹金凤1,崔娜1,杨爱敏1,姜蕾1,郝桂敏1   

  1. 1.河北医科大学第二医院生殖科, 石家庄 050000;
    2.邢台市人民医院妇产科, 河北 邢台 054031
  • 收稿日期:2013-02-22 出版日期:2013-06-10 发布日期:2013-06-10
  • 通讯作者: 郝桂敏,E-mail:haoguimin@163.com
  • 基金资助:

    河北省科学技术厅基金资助项目(11276103D-29);河北省人口和计划生育委员会科技研究计划项目(2012-A07)。

Effect of letrozole on the ovulation stimulation among the patients with polycystic ovary syndrome

WANG Wei1, HUA Tian2, CAO Jin-feng1, CUI Na1, YANG Ai-min1, JIANG Lei1, HAO Gui-min1   

  1. 1. Department of Reproduction, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China;
    2. Department of Gynecology, Xingtai People’s Hospital, Xingtai 054031, Hebei, China
  • Received:2013-02-22 Online:2013-06-10 Published:2013-06-10

摘要:

目的   比较来曲唑(LE)、克罗米芬(CC)和尿促性素(HMG)在多囊卵巢综合征(PCOS)促排卵中的效果,探讨LE在PCOS促排卵中的优势。方法   有生育要求的PCOS患者150例,共239个促排卵周期,随机分为CC组、LE组、CC+HMG组、LE+HMG组和HMG组。比较各组患者绒促性素(HCG)注射日成熟卵泡(卵泡直径≥14mm)的数量、多于3个卵泡的例数、排卵率、卵泡不破裂黄素化综合征(LUFS)发生率、HCG注射日子宫内膜的厚度、尿促性素用量、诱导排卵时间、周期妊娠率。结果   LE组和LE+HMG组患者HCG注射日成熟卵泡的数量和多于3个卵泡的例数均显著低于其他3组(P<0.05);CC组排卵率均低于其他4组,而LUFS的发生率高于其他4组(P<0.01);LE组、LE+HMG组和HMG组HCG注射日子宫内膜的厚度均显著高于其他2组(P<0.05);LE+HMG组中HMG的用量低于CC+HMG和HMG组(P<0.05);HMG组诱导排卵时间显著长于其他4组(P<0.05); CC组妊娠率明显低于其他4组(P<0.05)。结论   在PCOS促排卵中,LE较CC和HMG排卵率高,LUFS发生率低,单卵泡发育率高,HCG注射日子宫内膜的厚度高,妊娠率高,节约促排卵时间和费用。

关键词: 来曲唑;多囊卵巢综合征;促排卵;克罗米芬;尿促性素

Abstract:

Objective   To compare the effects of letrozole (LE), clomiphene citrate (CC) and human menopausal gonadotropin (HMG) on ovarian stimulation in the patients with polycystic ovary syndrome (PCOS), and to investigate the advantage of LE. Methods   One hundred and fifty patients with PCOS were randomly divided into CC group, LE group, CC+HMG group, LE+HMG group and HMG group. We compared the numbers of mature follicle (diameters≥14mm) on the human chorionic gonadotrophin (HCG) injection day, cases with more than three mature follicles, ovulation rate, incidence rate of luteinized unruptured folliclesyndrome (LUFS), endometrial thickness on the HCG injection day, amount of HMG, duration of induced ovulation, and the pregnancy rate of patients in these different groups. Results   The amount of mature follicle and the cases of patients with more than three mature follicles on the HCG injection day were both significantly less in LE and LE+HMG groups than those in other groups (P<0.05). The lower ovulation rate and higher incidence rate of LUFS were shown in CC group, which had significant differences with other groups (P<0.01). The endometrial thicknesses on the HCG injection day were significantly higher in LE, LE+HMG, and HMG groups, compared with other groups (P<0.05). The amount of HMG was significantly lower in LE+HMG group than CC+HMG and HMG groups (P<0.05). It showed that the duration of induced ovulation in HMG group was longer (P<0.05), and the pregnancy rates were significantly lower in CC group(P<0.05). Conclsion   Compared with CC and HMG treatment, LE showed higher ovulation rate, lower incidence rate of LUFS, higher rate of one follicle, higher endometrial thickness on the HCG injection day, higher pregnancy rate, the shorter duration of induced ovulation, and less cost more in ovulation induction of PCOS.

Key words: Letrozole; Polycystic ovary syndrome; Clomiphene citrate; Induced ovulation; Human menopausal gonadotropin

中图分类号: 

  • R711.6
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[2] 郑荣华,石玉华,盛燕,高芹,高选,陈子江. 多囊卵巢综合征患者白细胞计数的变化特点[J]. 山东大学学报(医学版), 2012, 50(7): 78-80.
[3] 杨慧军1, 李媛1, 吴克良1, 李梅1, 车詈2, 马水英1, 仲万霞1, 陈子江1. 授精后5h补救性卵胞浆内单精子显微注射的临床应用价值[J]. 山东大学学报(医学版), 2011, 49(10): 139-142.
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