干扰素-β对SAH致心肺损害的影响

山东大学学报(医学版) ›› 2012, Vol. 50 ›› Issue (5): 32-35.

干扰素-β对SAH致心肺损害的影响

孟凡良1, 孟雷2，彭洪海2，史建国2，刘殿玮2，姜勇2

1.山东大学医学院, 济南 250012； 2.山东大学附属济南市中心医院神经外科，济南 250013

收稿日期:2011-12-14 出版日期:2012-05-10 发布日期:2012-05-10
通讯作者: 姜勇(1961- ),男,教授,主任医师,主要从事神经外科基础与临床的研究。 E-mail: jyong9938@yahoo.com.cn
作者简介:孟凡良(1982- ),男,硕士研究生,主要从事神经外科基础与临床的研究。
基金资助:
济南市科技局科技攻关计划基金资助项目(0610382);济南市科技局发展计划基金资助项目(200807032)。

Effects of interferon-β on cardiopulmonary function after
subarachnoid hemorrhage

MENG Fan-liang1， MENG Lei2, PENG Hong-hai2, SHI Jian-guo2, LIU Dian-wei2, JIANG Yong2

1. School of Medicine, Shandong University, Jinan 250012, China;
2. Department of Neurosurgery, Jinan Central Hospital Affiliated to
Shandong University， Jinan 250013, China

Received:2011-12-14 Online:2012-05-10 Published:2012-05-10

摘要/Abstract

摘要：

目的研究蛛网膜下腔出血(SAH)后血管内皮细胞生长因子C(VEGF-C)在心、肺的表达及重组人干扰素-β(INF-β)对心肺功能的保护作用。方法采用小脑延髓池注血法建立蛛网膜下腔出血模型，将实验动物随机分为正常对照组、假手术组、SAH未治疗组和SAH治疗组，采用免疫组织化学SP法观察VEGF-C在心脏、肺脏中的表达并测定积分光密度值(IOD)。结果与假手术组相比， SAH未治疗组和SAH治疗组，心脏和肺脏中VEGF-C的表达在24、48、72h时均明显升高(P均＜0.05)；SAH治疗组24、48、72h时， VEGF-C在心脏和肺脏中的表达均低于SAH未治疗组(P均＜0.05)。结论 SAH引起的全身炎症反应导致心、肺缺血，使VEGF-C的表达升高，INF-β可抑制心、肺等脏器的炎症反应并改善组织缺血。

关键词: 蛛网膜下腔出血；血管内皮生长因子-C；干扰素β；大鼠

Abstract:

Objective To study expression of vascular endothelial growth factor-c(VEGF-C) in hearts and lungs after subarachnoid hemorrhage(SAH) and to evaluate the protection of interferon-β(INF-β). Methods The rat SAH model was established. The rats were randomly divided into the control group, the sham operation group, the SAH group with therapy and the SAH group without therapy. Expressions of VEGF-C in the hearts and lungs were detected. Results VEGF-C expressions in hearts and lungs in the SAH group with therapy and the SAH group without therapy were higher than the sham operation group. VEGF-C expression in hearts and lungs in the SAH group without therapy was lower than the SAH group with therapy. Conclusion SAH leads to cardiopulmonary ischemia through systemic inflammatory response. The INF-β can protect the organs by restraining the systemic inflammatory response.

Key words: Subarachnoid hemorrhage; Vascular endothelial growth factor-c; Interferonbeta; Rats

中图分类号:

R743.35

孟凡良1, 孟雷2，彭洪海2，史建国2，刘殿玮2，姜勇2. 干扰素-β对SAH致心肺损害的影响[J]. 山东大学学报(医学版), 2012, 50(5): 32-35.

MENG Fan-liang1， MENG Lei2, PENG Hong-hai2, SHI Jian-guo2, LIU Dian-wei2, JIANG Yong2. Effects of interferon-β on cardiopulmonary function after
subarachnoid hemorrhage[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(5): 32-35.

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