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山东大学学报(医学版) ›› 2014, Vol. 52 ›› Issue (10): 72-76.doi: 10.6040/j.issn.1671-7554.0.2014.222

• 临床医学 • 上一篇    下一篇

声脉冲辐射力成像技术对甲状腺良、恶性结节的鉴别诊断价值

姜丽丽1, 马喆2, 马楚云3, 何远流1, 陶国伟2, 刘村1, 耿群4, 汤婷婷5, 王音4   

  1. 1. 山东大学附属济南市中心医院超声科, 山东 济南 250013;
    2. 山东大学齐鲁医院超声科, 山东 济南 250012;
    3. 成都军区总院超声科, 四川 成都 610083;
    4. 山东大学医学院, 山东 济南 250012;
    5. 济南市第四人民医院超声科, 山东 济南 250031
  • 收稿日期:2014-04-14 修回日期:2014-09-11 出版日期:2014-10-10 发布日期:2014-10-10
  • 通讯作者: 马喆。E-mail:mazhe315@163.com E-mail:mazhe315@163.com
  • 基金资助:
    山东大学自主创新基金(2012TS139);山东省自然科学基金(ZR2010HQ035);山东省科技发展计划(2012GSF11860)

Value of acoustic radiation force impulse imaging technology for differentiating benign from malignant thyroid nodules

JIANG Lili1, MA Zhe2, MA Chuyun3, HE Yuanliu1, TAO Guowei2, LIU Cun1, GENG Qun4, TANG Tingting5, WANG Yin4   

  1. 1. Department of Ultrasonography, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China;
    2. Department of Ultrasonography, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    3. Department of Ultrasonography, Chengdu Military General Hospital, Chengdu 610083, Shandong, China;
    4. School of Medicine, Shangdong University, Jinan 250012, Shandong, China;
    5. Department of Ultrasonography, Jinan Fourth People's Hospital, Jinan 250031, Shandong, China
  • Received:2014-04-14 Revised:2014-09-11 Online:2014-10-10 Published:2014-10-10

摘要: 目的 探讨声脉冲辐射力成像技术(ARFI)中声触诊组织定量技术(VTQ)在甲状腺良、恶性结节鉴别诊断中的应用。方法 选择山东大学齐鲁医院超声科2011年9月至2012年10月期间,经超声VTQ检测并手术或穿刺活检后病理证实的312个甲状腺结节(来自268例患者),据病理结果分为良性结节组(n=196)和恶性结节组(n=116),以相应的结节周围组织为良性结节周围组(n=196)和恶性结节周围组(n=116),对各组的VTQ检测结果进行回顾性分析并做统计学处理。结果 ①恶性结节组的VTQ测值显著高于其他3组(P<0.001);②良性结节组的VTQ测值与良性结节周围组、恶性结节周围组无显著差异(P=0.174、P=0.812、P=0.063)。③据ROC曲线计算约登指数,确定界值3.25 m/s,为ROC曲线上的最佳临界点,对应的敏感度为89%,特异度为70%。结论 超声VTQ技术对甲状腺良、恶性结节具有重要的鉴别诊断作用。

关键词: 声脉冲辐射力成像技术, 鉴别诊断, 声触诊组织定量, 甲状腺结节

Abstract: Objective To evaluate the diagnostic value of virtual touch tissue quantification (VTQ) of acoustic radiation force impulse (ARFI) elasticity imaging for differentiating benign from malignant thyroid lesions. Methods Two hundred and sixty-eight patients with 312 thyroid nodules undergoing thyroid nodules surgeryor biopsies after thyroid nodules VTQ examination were retrospectively reviewed. The patients were selected from the Department of Ultrasonography, Qilu Hospital of Shandong University,during Sep. 2011 to Oct. 2012. All cases were divided into four groups, benign nodules group(n=196),parenchyma surrounding benign nodules group(n=196), malignant nodules group(n=116), and parenchyma surrounding malignant nodules group(n=116), according to the pathological results. TheVTQ values of the four groups were detected and statistically analyzed. Results ①VTQ value of malignant thyroid nodules group was significantly higher than those of the other groups(P<0.001);②No significant difference was found among the VTQ values of parenchyma surrounding benign nodules group, benign nodules group and parenchyma surrounding malignant nodules group(P=0.174, P=0.812, P=0.063);③According to the receiver operating characteristic(ROC) curve, 3.25 m/s was determined as the optimized point of the diagnostic value. When an SWV greater than 3.25 m/s was used for the diagnosis of malignant nodules and less than 3.25 m/s for the diagnosis of benign nodules, the sensitivity and specificity of ARFI imaging were 89% and 70%, respectively. Conclusion VTQ technology is more objective in quantitatively evaluating tissue hardness. VTQ technology shows better diagnostic value in the evaluation of benign and malignant thyroid nodules.

Key words: Acoustic radiation force impulse technology, Virtual touch tissue quantification, Differentiation, Thyroid nodules

中图分类号: 

  • R445.1
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