慢性肝病患者血浆中凝血酶激活的纤溶抑制物(TAFI)水平与慢性肝损伤的相关性

山东大学学报(医学版) ›› 2012, Vol. 50 ›› Issue (4): 83-.

慢性肝病患者血浆中凝血酶激活的纤溶抑制物(TAFI)水平与慢性肝损伤的相关性

王胜江1，徐成伟2

山东大学 1.医学院，济南 250012； 2.第二医院检验科，济南 250033

收稿日期:2011-11-28 出版日期:2012-04-10 发布日期:2012-04-10
通讯作者: 徐成伟(1964- )，男，教授，主要从事血栓与止血的研究。E-mail：xuchengwei-jyk@163.com
作者简介:王胜江(1987- )，男，硕士研究生，主要从事血栓与止血的研究。
基金资助:
山东省自然科学基金资助项目(ZR2009CM083)

TAFI levels in patients with chronic liver diseases:
correlation with chronic hepatic damage

WANG Sheng-jiang1， XU Cheng-wei2

1. School of Medicine, Shandong University, Jinan 250012, China;
2. Department of Laboratory Medicine， The Second Hospital of Shandong University， Jinan 250033, China

Received:2011-11-28 Online:2012-04-10 Published:2012-04-10

摘要/Abstract

摘要：

目的检测慢性肝病患者外周血凝血酶激活的纤溶抑制物活性(TAFI：A)水平，并探讨其与不同类型慢性肝损伤之间的相关性。方法收集84例临床肝病患者和52例健康体检者的血液标本，采用发色底物法检测血浆TAFI：A，同时检测纤溶酶原活化物抑制剂(PAI-1)和组织型纤溶酶原激活物(t-PA)水平，并分析以上检测指标与不同类型慢性肝病间的相关性。结果与健康对照组比较，病例组血浆TAFI：A水平均显著降低(P<0.05)；血浆PAI-1水平显著增加(P<0.05)；血浆t-PA水平亦显著增加(P<0.05，原发性胆汁性肝硬化除外)。结论慢性肝损伤患者血浆TAFI：A水平降低，导致纤溶活性增加，是提示慢性肝病患者呈出血倾向的一项指标。

关键词: 凝血酶激活的纤溶抑制物；纤维蛋白溶解；肝病

Abstract:

Objective To study the correlation between thrombin-activatable fibrinolysis inhibitor (TAFI) levels and different types of chronic hepatic damage in patients with chronic hepatic diseases. Methods Blood samples were collected from 84 patients with chronic hepatic diseases (“Patient Group”) and 52 healthy individuals (“Control Group”). Plasma levels of TAFI: A, plasminogen activator inhibitor(PAI-1)and tissue plasminogen activator (t-PA)were measured using a chromogenic substrate method and ELISA. Results Compared with the Control Group, the Patient Group had significantly low TAFI levels (P<0.05), high PAI-1 levels (P<0.05), and high t-PA levels(P<0.05, except for the patients with primary biliary cirrhosis). Conclusion In patients with chronic hepatic diseases, the diminished plasma TAFI levels can ramp up fibrinolysis. This is an indicator of bleeding tendency.

Key words: Thrombin-Activatable Fibrinolysis Inhibitor； Fibrinolysis； Liver Disease

中图分类号:

R575.1

王胜江1，徐成伟2. 慢性肝病患者血浆中凝血酶激活的纤溶抑制物(TAFI)水平与慢性肝损伤的相关性[J]. 山东大学学报(医学版), 2012, 50(4): 83-.

WANG Sheng-jiang1， XU Cheng-wei2 . TAFI levels in patients with chronic liver diseases:
correlation with chronic hepatic damage[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(4): 83-.

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