关键词: 牙周炎；子痫前期；肿瘤坏死因子-α；白细胞介素-6；C-反应蛋白

Abstract:

Objective   To explore the change and possible relationship of serum levels of tumor necrosis factor-alpha (TNF-α)、 interleukin-6(IL-6)、 C-reactive protein(CRP) in patients with chronic periodontitis (CP) and preeclampsia (PE). Methods   A case-control study was carried out that included 42 preeclamptic and 42 non- preeclamptic pregnant women between 26 to 36 weeks of pregnancy.  Among them， 21 were patients with PE and CP (group PE+CP)， 21 were patients with CP (group CP)， 21 were patients with PE (group PE) and 21 were healthy volunteers (group H). The periodontal indexes such as PI, PD, AL and BOP were recorded and the serum levels of  TNFα、 IL-6、 CRP  were measured. ResultsThe periodontal indexes including probing depth(PD)、 attachment loss(AL) and bleeding on probing(BOP) were significantly different among the four groups. In the (PE+CP)、 PE and CP groups， the serum levels of TNF-α、 IL-6、 CRP levels were significantly higher compared to those in the H group (P<0.05). Furthermore， the TNF-α、 IL-6、 CRP  levels  were  significantly  higher in the(PE+CP)group than those in the PE and CP groups (P<0.05). Conclusion      TNF-α、 IL-6、 CRP  may  be  closely  related  to  the  pathogenesis of preeclampsia  and  chronic periodontitis. A certain correlation may exist between preeclampsia and chronic periodontitis.

Key words: Periodontitis；  Preeclampsia； Tumor necrosis factor-alpha；  Interleukin-6； C-reactive protein