血浆网膜素-1和白介素-18水平与冠心病的关系

山东大学学报(医学版) ›› 2012, Vol. 50 ›› Issue (10): 86-89.

血浆网膜素-1和白介素-18水平与冠心病的关系

李秀芹1,2,3，卜培莉1,2

1.山东大学齐鲁医院心内科，济南 250012； 2.教育部和卫生部心血管重构与功能研究重点实验室，济南 250012；
3.潍坊市人民医院心内科, 山东潍坊 261041

收稿日期:2012-02-21 出版日期:2012-10-10 发布日期:2012-10-10
通讯作者: 卜培莉(1962- )，女，教授，博士生导师，主要从事高血压、冠心病及动脉硬化的基础和临床研究。E-mail: bupeili@medmail.com.cn
作者简介:李秀芹(1970- )，女，博士研究生，主治医师，主要从事冠心病和动脉硬化的基础与临床研究。

The study of the relationship between plasma omentin-1,
interleukin-18 levels and coronary disease

LI Xiu-qin1，2，3, BU Pei-li1,2

1. Department of Cardiology of Qilu Hospital of Shandong University, Jinan 250012, China;
2. Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and
Chinese Ministry of Public Health, Jinan 250012, China; 3. Department of Cardiology of
Weifang People′s Hospital, Weifang 261041, Shandong, China

Received:2012-02-21 Online:2012-10-10 Published:2012-10-10

摘要/Abstract

摘要：

目的通过检测冠心病患者和正常对照组血浆中网膜素-1和白介素-18(interleukin-18,IL-18)的水平，探讨血浆网膜素-1和IL-18的水平变化与冠心病发病的关系。方法选择2011年5月至11月住院患者74例(排除糖尿病等)，分为冠心病组54例(其中不稳定型心绞痛组32例，稳定型心绞痛组22例)和对照组20例。于入院次日抽取空腹静脉血，采用酶联免疫吸附测定法(enzyme-linked immunosorbent assay,ELISA)测定血浆网膜素-1和IL-18水平，并测量身高、体质量、血压、空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇等指标。结果冠心病组血浆网膜素-1水平较对照组低，两组差异有统计学意义(P＜0.01)，冠心病组血浆IL-18水平较对照组高，两组差异有统计学意义(P＜0.05)。结论冠心病患者血浆网膜素-1水平下降和IL-18水平上升，可能在冠心病的发病机制中起一定作用。

关键词: 网膜素-1；白介素-18；冠心病；不稳定型心绞痛；稳定型心绞痛

Abstract:

Objective To investigate the relationship between plasma omentin-1, interleukin-18 (IL-18) levels and the pathogenesis of coronary disease through detecting plasma omentin-1 and IL-18 levels of patients with coronary disease and patients in the control group. Methods 74 patients (without diabetes mellitus) hospitalized from May 2011 to November 2011 were divided into two groups 54 cases in the coronary disease group(32 cases in the unstable angina pectoris group, 22 cases in the stable angina pectoris group), and 20 cases in the control group. Venous blood samples were collected from the patients after an overnight fast the next day after admission to hospital. The plasma omentin-1 and IL-18 levels were detected by enzyme-linked immunosorbent assay( ELISA), and the height, body mass, blood pressure, fasting blood sugar, total cholestero1, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol and other indicators were measured． Results The plasma omentin1 level in the coronary disease group was lower than that in the control group, and the difference between the two groups was statistically significant(P＜0.01). The plasma IL18 level in the coronary disease group was higher than that in the control group, and the difference between the two groups was statistically significant (P＜0.05). Conclusion The plasma omentin-1 levels decrease and IL-18 levels increase in patients with coronary disease, which may play a role in the pathogenesis of the coronary disease.

Key words: Omentin-1; Interleukin-18; Coronary disease; Unstable angina pectoris; Stable angina pectoris

中图分类号:

R541.4

李秀芹1,2,3，卜培莉1,2. 血浆网膜素-1和白介素-18水平与冠心病的关系[J]. 山东大学学报(医学版), 2012, 50(10): 86-89.

LI Xiu-qin1，2，3, BU Pei-li1,2. The study of the relationship between plasma omentin-1,
interleukin-18 levels and coronary disease[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(10): 86-89.

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