胰腺癌组织中MMP-9、IL-6的表达及其与临床病理分型的关系

山东大学学报(医学版) ›› 2011, Vol. 49 ›› Issue (9): 99-.

胰腺癌组织中MMP-9、IL-6的表达及其与临床病理分型的关系

古力巴哈尔·阿不力米题1，龚晓瑾1，古力娜尔·库尔班2

新疆医科大学 1.第二附属医院病理科，乌鲁木齐 830063；
2.基础医学院病理学教研室，乌鲁木齐 830054

收稿日期:2011-03-03 出版日期:2011-09-10 发布日期:2011-09-10
通讯作者: 古力娜尔·库尔班，女，副教授，主要从事肿瘤分子病理学方面的研究。E-mail: 654508376@qq.com
作者简介:古力巴哈尔·阿不力米题(1958- )，女，副主任医师，主要从事肿瘤病理方面的研究。

Expressions of MMP-9 and IL-6 in pancreatic neoplasm and their relationships with clinical pathological classification

GULIBAHAER·Abulimiti1, GONG Xiao-jin1, GULINAER·Kuerban2

1. Department of Pathology, Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830063, China;
2. Department of Pathology, College of Preclinical Medicine, Xinjiang Medical University, Urumqi 830054, China

Received:2011-03-03 Online:2011-09-10 Published:2011-09-10

摘要/Abstract

摘要：

目的探讨基质金属蛋白酶-9(MMP-9)和白细胞介素-6(IL-6)在人胰腺癌组织中的表达及其与临床病理分型的关系。方法采用免疫组织化学染色法检测50例胰腺癌组织及20例正常胰腺组织中MMP-9及IL-6的表达情况，探讨其与临床病理分型的关系。结果胰腺癌组织中MMP-9和IL-6的阳性表达率明显高于正常胰腺组织。Ⅲ～Ⅳ期胰腺癌组织中MMP-9和IL-6的阳性表达率明显高于Ⅰ～Ⅱ期。在高、中、低3种分化程度不同的胰腺癌组织中，MMP-9、IL-6表达的阳性率随组织分化程度的降低呈升高的趋势。结论 MMP-9与IL-6在胰腺癌中的表达显著增加，其高表达可能与胰腺癌的发生发展密切相关。

关键词: 胰腺肿瘤；基质金属蛋白酶-9；白介素-6

Abstract:

Objective To detect expressions of matrix metalloproteinases-9 (MMP-9) and interleukin-6 (IL-6) in pancreatic neoplasm, and to analyze the relationships between the two cytokines and clinical pathological classification. Methods The immunohistochemical technique was used to explore expressions of MMP-9 and IL-6 in 50 cases of human pancreatic neoplasm and 20 cases of non-tumor pancreatic tissues, and the relationships between their expressions and the clinical pathological classification were analyzed. Results Expressions of MMP-9 and IL-6 were significantly higher in pancreatic neoplasm tissue than in normal pancreatic tissues. Expressions of MMP-9 and IL6 were significantly higher in stagesⅢ-Ⅳ than in stages Ⅰ-Ⅱ. In pancreatic neoplasm tissue, MMP-9 and IL-6 expression rates decreased with different degrees of differentiation (high, moderate and low). Conclusion Expressions of MMP-9 and IL-6 in pancreatic neoplasm are increased, and high expressions may correlate with the occurrence and development of pancreatic carcinoma.

Key words: Pancreatic neoplasms; Matrix Metalloproteinases-9; Interleukin-6; Immunohistochemistry

中图分类号:

R735.9

古力巴哈尔·阿不力米题1，龚晓瑾1，古力娜尔·库尔班2. 胰腺癌组织中MMP-9、IL-6的表达及其与临床病理分型的关系[J]. 山东大学学报(医学版), 2011, 49(9): 99-.

GULIBAHAER·Abulimiti1, GONG Xiao-jin1, GULINAER·Kuerban2. Expressions of MMP-9 and IL-6 in pancreatic neoplasm and their relationships with clinical pathological classification[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(9): 99-.

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