多胺代谢与肿瘤治疗

山东大学学报(医学版) ›› 2011, Vol. 49 ›› Issue (10): 67-.

多胺代谢与肿瘤治疗

刘贤锡

山东大学医学院生物化学与分子生物学研究所, 济南 250012

收稿日期:2011-08-04 出版日期:2011-10-10 发布日期:2011-10-10
作者简介:刘贤锡，山东大学三级教授、博士生导师。1945年出生于山东省蓬莱县，1974年山东医学院医疗专业毕业，并留校任生物化学教师。

Polyamine Metabolism and Cancer Therapy

LIU Xian-xi

Institute of Biochemistry and molecular Biology， Shandong University School of Medicine， Jinan 250012, China

Received:2011-08-04 Online:2011-10-10 Published:2011-10-10

摘要/Abstract

摘要：

多胺代谢在肿瘤发生发展中起重要作用。鸟氨酸脱羧酶(ODC)和S腺苷甲硫氨酸脱羧酶(SAMDC)是多胺生物合成的两个关键酶。ODC和SAMDC的抑制剂治疗肿瘤的作用，在体外实验和动物水平的研究中已获得认可，但是，在临床实验中却因其毒副作用而遭受质疑。近年的研究发现，肿瘤组织中ODC和SAMDC基因表达水平增加，而沉默二者的基因表达，则可抑制肿瘤的增殖和侵袭活性，这可能为以多胺代谢为靶标探讨肿瘤防治技术的研究提供了新的思路。本文概述了多胺代谢与肿瘤治疗关系的研究进展。

关键词: 多胺代谢;鸟氨酸脱羧酶;S-腺苷甲硫氨酸脱羧酶;抑制剂;基因沉默;肿瘤治疗

Abstract:

Metabolism of Polyamine plays an important role in tumor growth and progress. Ornithine Decarboxylase (ODC) and S-adenosylmethionine Decarboxylase (SAMDC) are two key enzymes in the pathway of polyamine synthesis. The antitumor activities of ODC and SAMDC inhibitors have been well-established in in-vitro and animal experiments. However, their applications are limited in clinic due to their toxicity. Recent research found that expression of ODC and SAMDC are up-regulated in tumor tissue and knockdown of these two genes could inhibit tumor cell proliferation and migration. These studies provide new therapeutic approach for cancer prevention and treatment on the targets of polyamine metabolism. In this review, we summarize the new progress on relationship between polyamine metabolism and cancer therapy.

Key words: Polyamine metabolism; Ornithine decarboxylase; Sadenosylmethionine decarboxylase; Inhibitor; Knockdown of gene; Cancer therapy

中图分类号:

R730.53

刘贤锡. 多胺代谢与肿瘤治疗[J]. 山东大学学报(医学版), 2011, 49(10): 67-.

LIU Xian-xi. Polyamine Metabolism and Cancer Therapy[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(10): 67-.

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