C反应蛋白与川崎病并发冠状动脉病变的关系

山东大学学报(医学版) ›› 2011, Vol. 49 ›› Issue (8): 128-132.

C反应蛋白与川崎病并发冠状动脉病变的关系

赵丽丽1，王一彪2，索琳2

1.河南省南阳市中心医院儿科，河南南阳 473009； 2.山东大学第二医院儿科，济南 250033

收稿日期:2010-11-09 出版日期:2011-08-10 发布日期:2011-08-10
通讯作者: 王一彪(1963- )，男，主任医生，主要从事小儿心血管专业。 E-mail: wangyibiao@sdu.edu.cn
作者简介:赵丽丽(1977- )，女，主治医师，硕士研究生,主要从事小儿心血管专业。

Relation between C-reactive protein and coronary artery lesions secondary to Kawasaki disease

ZHAO Li-li1, WANG Yi-biao2, SUO Lin2

1. Department of Pediatrics, Nanyang Central Hospital, Nanyang 473009, Henan, China;
2. Department of Pediatrics, Second Hospital of Shandong University, Jinan 250033, China

Received:2010-11-09 Online:2011-08-10 Published:2011-08-10

摘要/Abstract

摘要：

目的探讨C反应蛋白(CRP)与川崎病患儿并发冠状动脉病变的关系。方法全面检索各中文数据库，收集2000年1月至2009年12月国内公开发表的和学位论文中关于川崎病并发冠状动脉病变与CRP有关的临床资料，采用Cochrane协作网提供的Review Manger软件(Revman4．2)，对所纳入的研究数据的计数资料进行Meta分析，根据文献异质性检验结果，选择固定效应模型，计算比值比及其95％的可信区间，并行敏感性分析及偏倚性分析。计量资料计算加权均数差(WMD)及其95％的可信区间。结果共有19项研究符合纳入标准，计数资料统计结果示，CRP>100mg/L［OR=2.37，95%CI=(1.49,3.77)，P=0.0003］；计量资料统计结果示，WMD=19.02，95%CI=(11.98,26.05)， P<0.00001。结论 CRP与中国川崎病患儿发生冠脉病变密切相关，CRP>100mg/L为其高危因素之一。

关键词: C反应蛋白；川崎病；冠状动脉病变；Meta分析

Abstract:

Objective To discuss the relation of C-reactive protein(CRP) and coronary artery lesions(CAL) secondary to Kawasaki disease(KD) in children. Methods Papers and dissertations about relations of CRP and CAL secondary to KD published between January 2000 and December 2009 were retrieved from Chinese Databases. RavMan 4.2 provided by Cochrane Network was used for Meta analysis of count data. Fixed effects model was selected according to the heterogeneity test results of the literature. Sensitivity analysis was performed according to the different results. The publication bias was evaluated by funnel plots， and odds ratio (OR) and 95% confidence interval (95% CI) were estimated. Weighted mean difference(WMD) and 95% CI was used to analyze measurement data. Results 19 studies met the inclusion criteria. Statistical analysis results of the count data were as follows: CRP>100mg / L［OR=2.37,95% CI=(1.49,3.77), P=0.0003］; Statistical analysis results of the measurement data were as follows: WMD=19.02, 95%, CI=(11.98,26.05), P<0.00001. Conclusion CRP is closely related to CAL secondary to KD, and CRP>100mg /L is one of its risk factors.

Key words: C-reactive protein; Kawasaki disease; Coronary artery lesion；Meta analysis

中图分类号:

R725.4

赵丽丽1，王一彪2，索琳2. C反应蛋白与川崎病并发冠状动脉病变的关系[J]. 山东大学学报(医学版), 2011, 49(8): 128-132.

ZHAO Li-li1, WANG Yi-biao2, SUO Lin2. Relation between C-reactive protein and coronary artery lesions secondary to Kawasaki disease[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(8): 128-132.

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