妊娠期高血压疾病妇女外周血调节性T细胞和辅助性T细胞表达分析

山东大学学报(医学版) ›› 2011, Vol. 49 ›› Issue (6): 137-139.

妊娠期高血压疾病妇女外周血调节性T细胞和辅助性T细胞表达分析

曹霞，王莲莲,罗希

中国医科大学附属第四医院产科, 沈阳 110032

收稿日期:2010-10-11 出版日期:2011-06-10 发布日期:2011-06-10
作者简介:曹霞(1971- )，女，主治医师，硕士，主要从事育龄妇女产科常见病研究。
基金资助:
辽宁省博士启动、自然科学基金资助项目(20071054)。

Expression of regulatory T cells and helper T lymphocytes in the peripheral blood of pregnancy induced hypertension women

CAO Xia, WANG Lian-lian, LUO Xi

Department of Obstetrics, the Fourth Hospital of China Medical University, Shenyang 110032, China

Received:2010-10-11 Online:2011-06-10 Published:2011-06-10

摘要/Abstract

摘要：

目的分析妊娠期高血压疾病(PIH)妇女外周血调节性T细胞和辅助性T细胞表达变化。方法连续选择近期住院确诊的PIH 妇女27例(PIH组)，入选对象均接受了外周血调节性T细胞(CD+4CD+25 Treg 和CD+4CD+25 Foxp3+Treg)和辅助性T细胞(CD+3、CD+4、CD+8、CD+4/CD+8)检测，并与同期住院正常怀孕产妇 (对照组，20例)相同测试结果进行比较。结果调节性T细胞数据中，PIH组血清CD+4CD+25 Treg和CD+4CD+25 Foxp3+ Treg水平明显低于对照组(P均<0.05～0.01)。辅助性T细胞中，PIH组血清CD+4/CD+8表达水平明显高于对照组，而CD+8表达水平则显著低于对照组(P均<0.05～0.01)。结论 PIH患者存在明确的外周血调节性T细胞和辅助性T细胞异常表达。

关键词: 妊娠期高血压疾病；调节性T细胞；辅助性T细胞；外周血

Abstract:

Objective To analyze expressions of regulatory T cells and helper T lymphocytes in the peripheral blood of pregnancy induced hypertension (PIH) women. Methods 27 PIH women were selected to detect regulatory T cells (CD+4CD+25 Treg and CD+4CD+25 Foxp3+Treg) and helper T lymphocytes (CD+3、CD+4、CD+8、CD+4/CD+8) in the peripheral blood, and the testing results were compared with another 20 normal pregnant women during the same hospitalization. Results Levels of CD+4CD+25 Treg and CD+4CD+25 Foxp3+ Treg of the regulatory T cells in the PIH women were significantly lower than those in the control group(P<0.05-0.01). Level of CD+4/CD+8 of helper T lymphocytes in the PIH women was significantly higher than that in the control group(P<0.050.01), but level of CD+8 in the PIH women was significantly lower than that in the control group (P<0.05-0.01). Conclusion It is clearly indicated that expressions of regulatory T cells and helper T lymphocytes in the peripheral blood of PIH women are out of the normal range.

Key words: Pregnancy induced hypertension; Regulatory T cells； Helper T lymphocyte; Peripheral blood

中图分类号:

R714．25

曹霞，王莲莲,罗希. 妊娠期高血压疾病妇女外周血调节性T细胞和辅助性T细胞表达分析[J]. 山东大学学报(医学版), 2011, 49(6): 137-139.

CAO Xia, WANG Lian-lian, LUO Xi. Expression of regulatory T cells and helper T lymphocytes in the peripheral blood of pregnancy induced hypertension women[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(6): 137-139.

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