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山东大学学报(医学版) ›› 2011, Vol. 49 ›› Issue (5): 119-.

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奥扎格雷联合低分子肝素治疗进展性脑梗死的临床疗效

李红军1,陈春富2   

  1. 山东大学附属省立医院 1.医务部; 2.神经内科, 济南 250021
  • 收稿日期:2010-12-20 出版日期:2011-05-10 发布日期:2011-05-10
  • 通讯作者: 陈春富(1964- ),男,主任医师,博士后,博导,主要从事脑血管疾病、头痛的研究。 E-mail:chencf301@163.com
  • 作者简介:李红军(1970- ),男,副主任医师,硕士,主要从事急症、中毒性疾病的研究。 E-mail:zhiyebing@tom.com

Clinical effects of sodium ozagrel combined with low molecular weight  heparin on patients with progressive cerebral infarction

LI Hong-jun1, CHEN Chun-fu2   

  1. 1.  Medical Department; 2. Department of Neurology, Provincial Hospital Affiliated to
    Shandong University, Jinan 250021, China
  • Received:2010-12-20 Online:2011-05-10 Published:2011-05-10

摘要:

目的     观察奥扎格雷钠与低分子肝素联合治疗进展性脑梗死的疗效及安全性。方法     随机将急性进展性脑梗死患者112例分为治疗组和对照组各56例。对照组在临床常规治疗的基础上加用奥扎格雷钠80mg,静脉滴注,2次/d,连用14d;治疗组在对照组治疗方案的基础上再加用低分子肝素钠0.4mL皮下注射,2次/d,连用14d;治疗前、后依据美国国立卫生院卒中量表(NIHSS)评分及日常生活能力(BI)评分评定神经功能缺损程度,并监测肝肾功能、血尿常规、凝血4项及心电图。结果     与对照组相比,治疗组NIHSS、BI评分在治疗后1、2周时差异具有统计学意义(P<0.05, P<0.01)。血小板、凝血酶原时间均在正常范围内;两组均未见明显不良反应。结论     奥扎格雷钠与低分子肝素联合治疗进展性脑梗死疗效较好,使用安全。

关键词: 替德肝素;脑梗塞;治疗结果;奥扎格雷钠

Abstract:

Objective     To observe efficacy and safety of combined sodium ozagrel with low molecular weight heparin on patients with progressive cerebral infarction. Methods    112 cases of progressive cerebral infarction were randomly divided into the treatment group (56 cases) and the control group (56 cases). The control group was only administered 80mg of sodium ozagrel, bid, for 14 days. And the treatment group was administered 80mg of sodium ozagrel, bid, for 14 days and 0.4mL of low molecular weight heparin sodium injection, bid, for 14 days. The therapeutic effect was evaluated by the National Institutes of Health Stroke Scale (NIHSS) and the Bathal index (BI). Liver and renal function, blood and urinary routines, blood clotting routine and electrocardiogram (ECG) were detected before and after 14 days of treatment. Results     Compared with the control group, grades of NIHSS and BI in the treatment group were significantly lower after one (P<0.05) and two weeks (P<0.01). Both the number of platelets and blood coagulation time were within the normal range. There was no obvious side effect in either groups. Conclusion     Sodium ozagrel combined with low molecular weight heparin is an effective and safe therapy for progressive cerebral infarction.

Key words: Tedelparin; Brain infarction; Treatment out come;  Sodium ozagrel

中图分类号: 

  • R743.3
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