结肠癌中hTERT和P53蛋白表达及临床意义

山东大学学报(医学版) ›› 2011, Vol. 49 ›› Issue (4): 115-117.

结肠癌中hTERT和P53蛋白表达及临床意义

迟元卫1，陈健2，刘亮2，王敏3，齐莹莹2，刘君2

1. 山东大学校医院，济南 250010； 2. 山东大学齐鲁医院消化内科，济南 250012；
3. 山东大学齐鲁医院保健科，济南 250012

收稿日期:2010-12-14 出版日期:2011-04-10 发布日期:2011-04-10
通讯作者: 陈健（1964- ），男，博士，教授，硕士生导师，主要从事消化系肿瘤的临床研究。 E-mail：chenjian@medmail.com.cn
作者简介:迟元卫（1967- ），男，主治医师，主要从事消化系统疾病的临床研究。Email: Chiyuanwei123@sina.com

Expressions of hTERT and P53 and significance in colorectal carcinoma

CHI Yuan-wei1, CHEN Jian2, LIU Liang2, WANG Min3, QI Ying-ying2, LIU Jun2

1. Hospital of Shandong University, Jinan 250010, China;
2. Department of Digestion, Qilu Hospital of Shandong University, Jinan 250012, China;
3. Department of Health Care, Qilu Hospital of Shandong University, Jinan 250012, China

Received:2010-12-14 Online:2011-04-10 Published:2011-04-10

摘要/Abstract

摘要：

目的研究结肠癌中hTERT和P53表达情况、意义及两者之间的相互作用关系。方法应用免疫组织化学SABC法检测52例结肠癌及其相应癌旁正常组织中hTERT和P53的表达。结果 52例结肠癌组织中hTERT表达阳性率为80.8%(40/52)，而相应癌旁正常结肠组织中无1例阳性表达；52例结肠癌组织中阳性表达为38例，阳性率为73.1%(38/52)，相应癌旁正常结肠组织中同样无1例阳性表达。hTERT、P53的表达上调与患者性别、年龄、浸润深度无明显相关（P>0.05）, 而与分化程度、淋巴结转移、Dukes分期有明显相关（P<0.05）。同时，hTERT、P53的表达呈显著正相关（r=0.538，P<0.05）。结论 hTERT、P53可能参与了肿瘤生长和发展的共同通路，在结肠癌发生、发展和转移过程中起着重要作用。

关键词: 结肠肿瘤；hTERT；P53

Abstract:

Objective To investigate expressions , significance and interaction of hTERT and P53 in colorectal carcinomas. Method Expressions of hTERTand P53 were detected in 52 cases of tumor tissues and tumor-adjacent norma1 tissues by the immunohistochemical method of SABC. Results The positive rate of hTERT in colorectal cancer was 80.8%(40/52) and in cancer adjacent normal tissues was 0%; The positive rate of P53 in colorectal cancer was 73.1%(38/52) and in cancer adjacent normal tissues was 0%. Over-expression of hTERT and P53 had no relation with gender, age and tumor depth(P>0.05). but was significantly related to tumor differentiation, lymph node metastasis, and Dukes staging(P<0.05). hTERT and P53 expression was positively correlated(r=0.538, P<0.05）. Conclusion hTERT and P53 participate in common pathways in tumor development，progression and metastasis，and may play an important role in colorectal carcinomas．

Key words: Colorectal carcinoma; hTERT；P53

中图分类号:

R735.3+5

迟元卫1，陈健2，刘亮2，王敏3，齐莹莹2，刘君2. 结肠癌中hTERT和P53蛋白表达及临床意义[J]. 山东大学学报(医学版), 2011, 49(4): 115-117.

CHI Yuan-wei1, CHEN Jian2, LIU Liang2, WANG Min3, QI Ying-ying2, LIU Jun2. Expressions of hTERT and P53 and significance in colorectal carcinoma[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2011, 49(4): 115-117.

参考文献

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed