替莫唑胺对高级别脑胶质瘤疗效的Meta分析

山东大学学报(医学版) ›› 2012, Vol. 50 ›› Issue (6): 80-.

替莫唑胺对高级别脑胶质瘤疗效的Meta分析

王耀伍1，尹春丽1，张志勇1，张宏义1，张坤1，张志民2，廖珩1

1.唐山市工人医院神经外科，河北唐山 063000； 2.石家庄以岭医院神经外科，石家庄 050000

收稿日期:2012-03-16 出版日期:2012-06-10 发布日期:2012-06-10
通讯作者: 尹春丽(1979- )，女，主治医师，主要从事神经系统疾病及脑血管病的研究。 E-mail：chunliyin@163.com
作者简介:王耀伍(1975- ),男，主治医师，主要从事神经系统肿瘤的综合治疗及功能神经外科的研究

Meta-analysis of temozolomide for highgrade gliomas

WANG Yao-wu1, YIN Chun-li1, ZHANG Zhi-yong1, ZHANG Hong-yi1,
ZHANG Kun1, ZHANG Zhi-min2, LIAO Heng1

1. Department of Neurosurgery, Tangshan Gongren Hospital, Tangshan 063000, Hebei, China;
2. Department of Neurosurgery, Shijiazhuan yiling Hospital, Shijiazhang 050000, Hebei, China

Received:2012-03-16 Online:2012-06-10 Published:2012-06-10

摘要/Abstract

摘要：

目的比较不同治疗药物在高级别脑胶质瘤手术治疗后的效果，分析评价替莫唑胺的疗效。方法利用文献检索方法收集国内使用替莫唑胺治疗高级别脑胶质瘤的文献，对符合入选条件的文献，应用Stata软件中的Meta程序分析替莫唑胺对高级别脑胶质瘤的疗效。结果入选文献7篇，共纳入病例438例，其中治疗组227例，对照组211例。Meta分析结果显示，合并OR值为3.70，95%可信区间为2.37~ 5.79，Mantel-Haenszel的固定效应模型检验结果Z=5.75，P<0.01，表明替莫唑胺的总体疗效显著高于其他同类药物。结论替莫唑胺可作为当前阶段治疗高级别脑胶质瘤首选药物。

关键词: 高级别脑胶质瘤；替莫唑胺；Meta分析

Abstract:

Objective To compare and evaluate the effects of temozolomide and other drugs in the high-grade gliomas post-surgical treatment. Methods In this literature review study, papers on temozolomide for high-grade gliomas were collected and Meta-analysis was performed using Stata software. Results 7 papers were included. Of 438 patients, 227 were in the treatment group and 211 were in the control group. The Meta analysis results showed that M-H pooled OR was 3.70 and 95% CI was 2.37-5.79, while the Mantel-Haenszel test showed that Z was 5.75 and P<0.01, which indicated the effects of temozolomide was significantly better than other drugs. Conclusion At present, temozolomide can be used as the drug of choice for high-grade gliomas.

Key words: High-grade gliomas; Temozolomide; Meta analysis

中图分类号:

R739.4

王耀伍1，尹春丽1，张志勇1，张宏义1，张坤1，张志民2，廖珩1. 替莫唑胺对高级别脑胶质瘤疗效的Meta分析[J]. 山东大学学报(医学版), 2012, 50(6): 80-.

WANG Yao-wu1, YIN Chun-li1, ZHANG Zhi-yong1, ZHANG Hong-yi1, ZHANG Kun1, ZHANG Zhi-min2, LIAO Heng1 . Meta-analysis of temozolomide for highgrade gliomas[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(6): 80-.

参考文献

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