窄谱中波紫外线联合干扰素α-2b治疗蕈样肉芽肿对血清趋化因子CCL27的影响

山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (10): 105-107.

窄谱中波紫外线联合干扰素α-2b治疗蕈样肉芽肿对血清趋化因子CCL27的影响

司晓青1,辛琳琳1,李文飞1,李承明1,李春阳2

1.山东大学附属千佛山医院皮肤科, 济南 250014;
2.山东大学齐鲁医院皮肤科，济南 250012

收稿日期:2010-07-20 出版日期:2010-10-16 发布日期:2010-10-16
通讯作者: 李春阳（1949- ），女，博士，教授，博士生导师，主要从事皮肤病科学及医学真菌学方面的研究。
作者简介:司晓青（1975- ），女，博士研究生，主治医师，主要从事皮肤病科学方面的研究。 E-mail:sxqwjnsxq1@sina.com.cn

Effects of narrowband-ultraviolet B combined with interferon α-2b on serum CCL27 level of mycosis fungoides patients

SI Xiao-qing1, XIN Lin-lin1, LI Wen-fei1， LI Cheng-ming1, LI Chun-yang2

1. Department of Dermatology, Qianfoshan Hospital Affiliated to Shandong Univeristy, Jinan 250014， China；
2. Department of Dermatology, Qilu Hospital of Shandong Univeristy, Jinan 250012, China

Received:2010-07-20 Online:2010-10-16 Published:2010-10-16

摘要/Abstract

摘要：

目的观察窄谱中波紫外线(NB UVB) 联合干扰素(IFN)-α-2b治疗蕈样肉芽肿（MF）的临床疗效，并比较治疗前后患者血清趋化因子CCL27水平。方法对17例MF患者行重组人IFNα-2b肌肉注射联合NB-UVB照射治疗,于治疗前后分别采集患者血清,利用酶联免疫吸附试验(ELISA)测其血清CCL27浓度，以16例健康人血清为对照组。结果治疗前MF患者CCL27血清水平高于健康对照组（P＜0.01），联合治疗后17 例患者完全缓解率(CCR)为64.71%,部分缓解率(PCR)为29.41%,有效率(CCR+PCR)为94.12%；其治疗后的血清CCL27水平较治疗前显著下降（P＜0.01）。结论 NB-UVB照射联合IFNα-2b肌肉注射治疗蕈样肉芽肿是一种安全有效的方法，可降低患者血清CCL27水平。

关键词: 蕈样肉芽肿; 干扰素α-2b; 中波紫外线；窄谱；CCL27

Abstract:

Objective To observe the efficacy of narrowband-ultraviolet B (NB-UVB) combined with interferon α-2b in the treatment of mycosis fungoides (MF) patients and evaluate the effects of the procedures on serum CCL27 level. Methods Seventeen patients with MF were treated with NB-UVB combined with interferon α-2b. Patient′s sera were collected before and after treatment. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum CCL27 level. The control group consisted of sixteen healthy subjects. Results Serum CCL27 level of MF patients was significantly higher than that of the control group（P＜0.01）. The rate of complete clinical remission (CCR), partial clinical remission (PCR) and total response rate (CCR+PCR) were 64.71%, 29.41%, and 94.12%, respectively. Serum CCL27 level significantly decreased after the combined treatment（P＜0.01）. Conclusion NB-UVB combined with interferon α-2b in the treatment of MF patients is an effective and safe therapy which can decrease the serum CCL27 level.

Key words: Mycosis fungoides; Interferon α-2b; Ultraviolet B; Narrowband; CCL27

中图分类号:

R733.1

司晓青1,辛琳琳1,李文飞1,李承明1,李春阳2. 窄谱中波紫外线联合干扰素α-2b治疗蕈样肉芽肿对血清趋化因子CCL27的影响[J]. 山东大学学报(医学版), 2010, 48(10): 105-107.

SI Xiao-qing1, XIN Lin-lin1, LI Wen-fei1， LI Cheng-ming1, LI Chun-yang2. Effects of narrowband-ultraviolet B combined with interferon α-2b on serum CCL27 level of mycosis fungoides patients[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(10): 105-107.

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