肝移植后胆道并发症早期肝功能的变化

山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (10): 98-100.

肝移植后胆道并发症早期肝功能的变化

杨德君，张海斌，司马辉，朱楠，杨广顺

第二军医大学附属东方肝胆外科医院胆道二科，上海 200433

收稿日期:2010-04-30 出版日期:2010-10-16 发布日期:2010-10-16
通讯作者: 杨广顺（1951- ），男，教授，博导，主要从事肝癌规范化综合治疗与肝移植的临床与基础研究。E-mail:gs-yang00@yahoo.com
作者简介:杨德君（1981- ），男，硕士，医师，助教，主要从事肝癌肝移植的临床与基础研究。

Changes of liver function at the early phase of biliary complications following liver transplantation

YANG Dejun, ZHANG Hai-bin, SI MA- Hui, ZHU Nan, YANG Guang-shun

The Second Department of Biliary Tract Surgery, Eastern Hepatobiliary Hospital, The Second Military Medical University,
Shanghai 200433, China

Received:2010-04-30 Online:2010-10-16 Published:2010-10-16

摘要/Abstract

摘要：

目的探讨肝移植术后缺血性胆道并发症(ischemictype biliary complications, ITBC)早期肝功能变化特点。方法随访分析肝移植术后BC患者的临床表现，对BC患者早期肝功指标变化进行统计学分析。结果 181例肝移植中发生BC 26例(14.36%)。其中缺血性BC 11例，9例（81.82%）治疗效果差；BC患者早期ALP、rGT与TBIL、ALT的增幅出现分离现象；缺血性BC同非缺血性BC早期的TBIL、ALP、rGT有统计学差异。结论 BC发病早期更高的TBIL、ALP、rGT血清浓度提示缺血性胆道并发症可能，预后不良。

关键词: 肝移植；胆道并发症，缺血性；肝功能

Abstract:

Objective To explore the characteristic of early changes of liver function in ischemic-type biliary complications(ITBC) after liver transplantation(LT). Methods Clinical data of 181 patients receiving LT were collected, and results were retrospectively analyzed by follow-up. Early changes of liver function in ITBC were statistically analyzed. Results 26 (14.36%,26/181) liver recipients developed BC, including 11 cases of ischemictype BC, out of which 9（81.82%,9/11）had bad results. Statistical analysis revealed that TBIL,ALT, ALP and r-GT had different increases, and the increases of ALP and r-GT were more obvious. Ischemic-type BC had higher doses of TBIL, ALP and r-GT than other types. ConclusionHigher doses of TBIL,ALP and r-GT at the early phase may be a signal of the occurrence of ITBC, which has a poor prognosis.

Key words: Liver transplantation；Biliary complication，Ischemictype；Liver function

中图分类号:

R617

杨德君，张海斌，司马辉，朱楠，杨广顺 . 肝移植后胆道并发症早期肝功能的变化[J]. 山东大学学报(医学版), 2010, 48(10): 98-100.

YANG Dejun, ZHANG Hai-bin, SI MA- Hui, ZHU Nan, YANG Guang-shun. Changes of liver function at the early phase of biliary complications following liver transplantation[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(10): 98-100.

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