D2-40在胸腺上皮肿瘤中的表达及临床意义

山东大学学报(医学版) ›› 2012, Vol. 50 ›› Issue (7): 68-.

D2-40在胸腺上皮肿瘤中的表达及临床意义

袁东风，江华，刘凡英

山东大学附属省立医院胸外科，济南 250021

收稿日期:2012-01-28 出版日期:2012-07-10 发布日期:2012-07-10
通讯作者: 刘凡英(1962- )，男，教授，主要从事胸外科疾病研究。 E-mail：liufanying2011@126.com
作者简介:袁东风(1984- )，男，硕士研究生，主要从事胸外科疾病研究。 E-mail: feng18985@126.com
基金资助:
山东省医药卫生科技发展计划(2009HZ058)

Clinical significances of D2-40 expression in thymic epithelial tumors

YUAN Dong-feng， JIANG Hua， LIU Fan-ying

Department of Thoracic Surgery， Provincial Hospital Affiliated to Shandong University, Jinan 250021, China

Received:2012-01-28 Online:2012-07-10 Published:2012-07-10

摘要/Abstract

摘要：

目的探讨D2-40在胸腺上皮肿瘤(TET)中的表达，分析D2-40表达与肿瘤侵袭和预后的关系。方法采用免疫组织化学染色法观察D2-40在160例胸腺上皮肿瘤和40例正常胸腺标本中的表达情况，术后连续随访5年以上。应用统计学软件分析D2-40表达与肿瘤侵袭和预后的关系。结果 D2-40在TET及正常胸腺中的阳性表达率分别为58.8%(94/160)和20%(8/40)，差异有统计学意义(P=0.013)。D2-40在TET中的表达与TET侵袭性有关(P<0.01)。D2-40阳性表达组和阴性表达组患者5年生存率分别为32%、90%(P<0.01)。结论 D2-40在TET中的表达高于正常胸腺组织，且随着侵袭性的增强，表达也增强。D2-40表达阳性的患者预后较差。

关键词: D2-40；胸腺上皮肿瘤；侵袭；预后

Abstract:

Objective To investigate the expression of D2-40 in thymic epithelial tumors (TET) and its significance in tumor invasion and prognosis. Methods Immunohistochemical method was used to assess the expression of D2-40 in 160 samples of thymic epithelial tumors and 40 samples of normal thymuses. All cases were followed-up for more than 5 years after operation. Statistics softwares were used to analyze the correlation between the expression of D2-40 and the tumor invasion and prognosis. Results The positive rate of D2-40 expression in 160 TET and 40 normal thymuses were 58.8%(94/160) and 20%(8/40) respectively, and the difference was statistically significant (P=0.013). The expression of D2-40 in TET was correlated with the invasion of TET (P<0.01). The 5-year-survival rates of the patients in the D2-40 expression positive group and the negative group were 32% and 90% respectively (P<0.01). Conclusion Expression of D2-40 is higher in the TET than in the normal thymus, which correlates with the aggression of TET. The patients with D2-40 positive expression have worse prognosis.

Key words: D2-40; Thymic epithelial tumor; Aggression; Prognosis

中图分类号:

R655.7

袁东风，江华，刘凡英. D2-40在胸腺上皮肿瘤中的表达及临床意义[J]. 山东大学学报(医学版), 2012, 50(7): 68-.

YUAN Dong-feng， JIANG Hua， LIU Fan-ying. Clinical significances of D2-40 expression in thymic epithelial tumors[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(7): 68-.

参考文献

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed