关键词: 2型糖尿病；周围神经病变；影响因素；Logistic回归；血糖；血脂

Abstract:

 Objective   To analyze factors influencing diabetic peripheral neuropathy(DPN) in elderly type 2 diabetic patients.  Methods   The data of 1069 patients more than 60 years old who were hospitalized in Beijing Hospital from 2003 to 2010 were retrospectively analyzed. The patients were divided into the DPN group and the non-diabetic peripheral neuropathy (NDPN) group according to electromyography. The clinical characteristics were compared and the influencing factors were analyzed.   Results   ① There were 873 patients(81.7%)in the DPN group and 196 patients(18.3%)in the NDPN group；② There were significant differences between the DPN group and NDPN group in the following indicators (P<0.01 or P<0.05)： age (71.20±6.70) years vs (69.54±5.92) years, duration of diabetes (12.42±8.02) years vs (9.89±7.67) years, glycosylated hemoglobin (HbA1c) (9.04±2.52)% vs (8.26±1.91)%, sex ratio(male/female) 450/423 vs 83/113, fasting C peptide (471.25±320.31)pmol/L vs (529.72±298.10)pmol/L, total cholesterol (TC ) (4.93±1.27)mmol/L vs (4.62±1.09)mmol/L, and low density lipoproteincholesterol(LDL)  (2.95±0.90 ) mmol/L vs (2.77±0.81)mmol/L. ③ Logistic regression analysis showed that ORs of age, duration of diabetes, HbA1c and TC were 1.047, 1.042, 1.152, and 1.275 respectively.   Conclusions   In elderly type 2 diabetic patients, age, duration of diabetes, HbA1c and TC were found to be the influencing factors of DPN. It seems to be beneficial to control both blood glucose and blood lipid to prevent and treat DPN in elderly type 2 diabetic patients.

Key words: Diabetes mellitus, type 2； Peripheral neuropathy； Influencing factors； Logistic regression； Blood glucose； Blood lipid