FOXP3在玫瑰糠疹、扁平苔藓、大斑块型副银屑病及蕈样肉芽肿中的表达及意义

山东大学学报(医学版) ›› 2012, Vol. 50 ›› Issue (2): 102-105.

FOXP3在玫瑰糠疹、扁平苔藓、大斑块型副银屑病及蕈样肉芽肿中的表达及意义

周秉侠1，郭淑兰1，许艳静2

1.山东大学齐鲁医院皮肤科，济南 250012； 2.青岛市中心医疗集团，山东青岛 266042

收稿日期:2011-03-31 出版日期:2012-02-10 发布日期:2012-02-10
通讯作者: 郭淑兰(1965- )，女，教授，硕士生导师，主要从事感染性及自身免疫性皮肤病的研究。 E-mail:guoshulan@medmail.com.cn
作者简介:周秉侠(1980- )，女，硕士研究生，主要从事自身免疫性皮肤病的研究。

Expression and significance of FOXP3 in pityriasis rosea, lichen
planus, large-plaque parapsoriasis and mycosis fungoides

ZHOU Bing-xia1, GUO Shu-lan1， XU yan-jing2

1. Department of Dermatology, Qilu Hospital of Shandong University, Jinan 250012,China；
2. Qingdao Central Medical Group, Qingdao 266042, Shandong, China

Received:2011-03-31 Online:2012-02-10 Published:2012-02-10

摘要/Abstract

摘要：

目的探讨叉头状转录因子P3(FOXP3)在玫瑰糠疹、扁平苔藓、大斑块型副银屑病及蕈样肉芽肿中的表达及意义。方法采用免疫组织化学EnVision法检测21例玫瑰糠疹、19例扁平苔藓、17例大斑块型副银屑病、22例蕈样肉芽肿及10例正常人皮肤中FOXP3的表达。结果玫瑰糠疹、扁平苔藓皮损中FOXP3+淋巴细胞阳性率与正常人皮肤中的表达差异无统计学意义(P>0.05)；大斑块型副银屑病与蕈样肉芽肿皮损中FOXP3+淋巴细胞阳性率均高于玫瑰糠疹、扁平苔藓及正常皮肤(P<0.05)，但其二者之间的表达差异无统计学意义(P>0.05)。结论 FOXP3+淋巴细胞阳性率在炎症性皮肤病、有肿瘤发展倾向的炎症性皮肤病及皮肤淋巴瘤中的表达有逐步增高的趋势。其增多可能为肿瘤细胞的免疫逃逸提供了条件，进而促进了肿瘤的发生、发展。

关键词: 叉头状转录因子P3 ；调节性T细胞；炎症性皮肤病；大斑块型副银屑病；蕈样肉芽肿；玫瑰糠疹；扁平苔藓

Abstract:

Objective To investigate expression and significance of forkhead box protein-3 (FOXP3) in normal skins, pityriasis rosea, lichen planus, large-plaque parapsoriasis, and mycosis fungoides. Methods The immunohistochemical EnVision method was applied to detect expression of FOXP3 in 21 cases of pityriasis rosea,19 cases of lichen planus,17 cases of large-plaque parapsoriasis, 22 cases of mycosis fungoides, and 10 normal skin controls. Results Rates of FOXP3-positive lymphocytes in lesions of pityriasis rosea and lichen planus had no significant difference compared with normal skins (P>0.05). Rates of FOXP3-positive lymphocytes in lesions of large-plaque parapsoriasis and mycosis fungoides were higher than those in pityriasis rosea, lichen planus, and normal skins(P<0.05), while no significant difference was found between large-plaque parapsoriasis and mycosis fungoides (P>0.05). Conclusions FOXP3-positive lymphocytes show a gradual increase tendency in inflammatory skin diseases, tumor tendency inflammatory skin diseases and cutaneous lymphoma. They may play an important role in immune escape of tumors and promote tumors′ occurrence and development.

Key words: Forkhead box protein-3； Regulatory T lymphocytes； Inflammatory skin diseases； Large-plaque parapsoriasis； Mycosis fungoides； Pityriasis rosea； Lichen planus

中图分类号:

R758.6

周秉侠1，郭淑兰1，许艳静2. FOXP3在玫瑰糠疹、扁平苔藓、大斑块型副银屑病及蕈样肉芽肿中的表达及意义[J]. 山东大学学报(医学版), 2012, 50(2): 102-105.

ZHOU Bing-xia1, GUO Shu-lan1， XU yan-jing2. Expression and significance of FOXP3 in pityriasis rosea, lichen
planus, large-plaque parapsoriasis and mycosis fungoides[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(2): 102-105.

参考文献

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed