关键词: 阻塞性睡眠呼吸暂停低通气综合征；瘦素受体；基因多态性

Abstract:

Objective   To investigate the relationship between the leptin receptor gene Pro1019Pro polymorphism and obstructive sleep apnea hypopnea syndrome(OSAHS). Methods   The genotypes of leptin receptor gene Pro1019Pro were detected by polymerase chain reactionrestriction fragment length polymorphisms(PCRRFLP) in 360 unrelated subjeces in Northern Han population(including 180 OSAHS subjects and 180 healthy controls). The difference were analyzed. Results   There was no significant difference in Genotypes and allele frequencies betwwen the OSAHS and  control group(P>0.05). The differences in neck circumference, abdominal circumference, and polysomnography (PSG) were not significant among the three genotypes(P>0.05). Conclusion   It is unlikely that the leptin receptor gene Pro1019Pro polymorphism may contribute to the pathogenesis of OSAHS.

Key words: Obstructive sleep apnea hypopnea syndrome (OSAHS); Leptin receptor; Gene polymorphism