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山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (3): 144-148.

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DWI及DCE-MRI在良恶性骨病鉴别诊断中的应用

曹金凤1,林祥涛1,2,王光彬2,肖连祥1,苗明明1,杨金永3   

  1. 1. 山东大学医学院, 济南 250012; 2. 山东省医学影像学研究所, 济南 250021;
    3. 泰山医学院, 山东 泰安 271016
  • 收稿日期:2009-11-11 出版日期:2010-03-16 发布日期:2010-03-16
  • 通讯作者: 林祥涛(1964- ),男,副教授,主要从事骨骼肌肉系统影像学研究。
  • 作者简介:曹金凤(1981- ),女,硕士研究生,主要从事MRI影像诊断学研究。 Email:cjf19810629@163.com

Application of MR diffusion-weighted imaging and dynamic contrast-enhanced MRI in differentiating benignskeletal lesions from malignant ones

CAO Jinfeng1, LIN Xiangtao1,2, WANG Guangbin2, XIAO Lianxiang1,MIAO Mingming1, YANG Jinyong3   

  1. 1. School of Medicine, Shandong University, Jinan 250012, China; 
    2. Shandong Medical Imaging Research Institute, Jinan 250021, China; 
    3. Taishan Medical University, Taian 271016, Shandong, China
  • Received:2009-11-11 Online:2010-03-16 Published:2010-03-16

摘要:

目的   探讨磁共振扩散加权成像(DWI)及MR动态增强成像(DCE-MRI)在良恶性骨病鉴别诊断中的应用价值。方法   47例骨病患者(良性18例,恶性29例)行DWI检查,其中36例(良性14例,恶性22例)再行DCE-MRI检查。分别于DWI和动态增强图像上测量ADC值、信号增强幅度(SEE)、早期动态增强斜率值(Slope值),判断TIC曲线类型,采用受试者操作特征(ROC)曲线选择良恶性病变鉴别诊断的阈值,计算各参数对病变潜在恶性估计的敏感度、特异度和准确度。结果   ① 47例病例中,良恶性两组病变的ADC值分别为(171.15±46.96)×10-5mm2/s、(100.14±26.47)×10-5mm2/s(P<0.05);以113.3×10-5mm2/s为阈值,ADC值对病变潜在恶性评估的准确性为86.4%;② 36例病例中,TIC曲线呈Ⅲ型者24例,恶性22例(91.67%),良性2例(8.33%);呈Ⅱ型者5例,Ⅰ型者7例,均为良性病变。若以Ⅲ型为恶性病变,Ⅰ、Ⅱ型均视为良性病变为诊断标准,则TIC类型对病变潜在恶性评估的准确性为94.3%;③ 良恶性两组间SEE、Slope值分别为227.96±172.08、325.6±125.86(P>0.05);(0.97±0.67)%/s、(2.53±0.91)%/s(P<0.05)。Slope值对病变潜在恶性估计的准确性为91.4%。结论  ①  DCEMRI比DWI更有助于鉴别骨骼系统病变良恶性,以TIC类型准确性最高,最有价值;② 良恶性病变间ADC值有一定交叉,DCEMRI存在重叠,联合应用DCE-MRI与DWI,会提高诊断的准确性和特异性。

关键词: 骨骼系统;磁共振成像;动态增强成像;扩散加权成像

Abstract:

Objective    To assess the diagnostic potential of DWI and DCE-MRI in differentiating benign from malignant skeletal lesions. Methods   DWI was performed on 47 patients and DCE-MRI on 36 patients using the Siemens Sonata 1.5T MR scanner. The ADC value was measured on DWI and SEE, and slope value and TIC type were gained on DCEMRI. Subjective overall performance of the two techniques was evaluated with ROC analysis. Results   ① The ADC value of benign and malignant groups was (171.15±46.96)×10-5mm2/s, (100.14±26.47)×10-5mm2/s(P<0.05). The diagnostic accuracy was 86.4%; ② In 36 patients, the Ⅲ curve was found in 24 (malignant for 22 and benign for 2),  theⅡcurve in 5 andⅠcurve in 7 (all were benign). As the Ⅲ curve was considered malignant and Ⅰ, Ⅱ curve were regarded as benign, the diagnostic accuracy of TIC type was 94.3%;  ③ SEE was  227.96±172.08and 325.6± 125.86 in benign and malignant groups respectively(P>0.05), and slope value was (0.97±0.67)%/s and (2.53±0.91)%/s (P<0.05). The diagnostic accuracy of slope value was 91.4%. Conclusion   ① DCE-MRI was more valuable than DWI in differentiating benign from malignant skeletal masses. The diagnostic accuracy of the TIC type was highest; ② The D combined use of CE-MRI and DWI can promote the accuracy in diagnosing suspicious skeletal masses.

Key words: Skeletal masses; Magnetic resonance imaging; Dynamic contrast enhancement; Diffusion-weighted imaging

中图分类号: 

  • R445.2
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